26110-96-3

Upstream product

• 1007-26-7 (2,2-dimethyl-1-propyl)benzene 
• 62558-02-5 1-(1-chloro-2,2-dimethylpropyl)-4-nitrobenzene 
• 55795-26-1 C₆H₉O₃^(1-)*Na⁽¹⁺⁾ 

Downstream Products

• 27856-10-6 4-(2,2-dimethyl-propyl)-phenylamine 
• 73526-82-6 2-(2,2-dimethyl-propyl)-phenylamine 

Relevant academic research and scientific papers

SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS

The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INHIBITORS

The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

METHODS OF TREATMENT OF AMYLOIDOSIS USING BI-CYCLIC ASPARTYL PROTEASE INHIBITORS

The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS

The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

Formation by SRN1 reactions and 1H N.M.R. properties of sterically encumbered 2,4,6-triaIkyIphenyl p-nitrobenzyl sulfides

Sterically hindered p-nitrobenzylic chlorides (1) and (2) react with the sodium salts of 2,4,6-trialkylbenzenethiols (3a)-(5a) by the SRN1 reaction to give good yields of the corresponding p-nitrobenzylic aryl sulfides (6)-(10). For example, th

STERIC AND ELECTRONIC LIMITATIONS OF THE SRN1 REACTION BETWEEN p-NITROBENZYLIC SUBSTRATES AND TERTIARY CARBANIONS

The SRN1 reaction between sterically hindered p-nitrobenzylic substrates and tertiary carbanions gives C-alkylated products whose yields depend on the steric bulk of both the benzylic substrate and the carbanion, and on the nature of the groups in the carbanion.