26118-67-2

Basic information

• Product Name: isopropylsulphamoyl chloride
• Synonyms: isopropylsulphamoyl chloride;(1-METHYLETHYL) SULFAMOYL CHLORIDE;Isopropylsulfamoyl chloride;Isopropylaminosulfonyl chloride;N-Isopropylchlorosulfonamide;N-Isopropylsulfamoyl chloride
• CAS NO: 26118-67-2
• Molecular Formula: C₃H₈ClNO₂S
• Molecular Weight: 157.61912
• EINECS: 247-472-6
• Mol File: 26118-67-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 212℃
• Flash Point: 82℃
• Appearance: /
• Density: 1.317
• Vapor Pressure: 0.18mmHg at 25°C
• Refractive Index: 1.467
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.53±0.40(Predicted)
• CAS DataBase Reference: isopropylsulphamoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: isopropylsulphamoyl chloride(26118-67-2)
• EPA Substance Registry System: isopropylsulphamoyl chloride(26118-67-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 26118-67-2(Hazardous Substances Data)

Usage

Uses

Isopropylaminosulfonic Acid is an reactant used in the synthesis of N-Alkylsulfamic Acid Derivatives.

InChI:InChI=1/C3H8ClNO2S/c1-3(2)5-8(4,6)7/h3,5H,1-2H3

Upstream product

• 42065-76-9 (1-Methylethyl)sulfamic Acid 
• 1795-48-8 Isopropyl isocyanate 
• 10521-91-2 5-phenylpentan-1-ol 
• 15572-56-2 isopropylamine hydrochloride 
• 79-00-5 1,1,2-trichloroethane 
• 38611-95-9 sodium isopropylsulphamate 
• 107-06-2 1,2-dichloro-ethane 
• 81363-76-0 propane-2-sulfonamide 
• 75-31-0 isopropylamine 

Downstream Products

• 67210-19-9 2-(isopropylsulfamoyl-amino)-cyclohex-1-enecarboxylic acid tert-butyl ester 
• 57836-30-3 Isopropyl-sulfamic acid [(2,6-dimethyl-phenyl)-propoxymethyl-carbamoyl]-methyl ester 
• 57836-40-5 Isopropyl-sulfamic acid [(2,6-diisopropyl-phenyl)-methoxymethyl-carbamoyl]-methyl ester 
• 57836-36-9 Isopropyl-sulfamic acid [(2,6-diethyl-phenyl)-methoxymethyl-carbamoyl]-methyl ester 
• 57836-33-6 Isopropyl-sulfamic acid [(2,6-dimethyl-phenyl)-isopropoxymethyl-carbamoyl]-methyl ester 
• 57836-38-1 Isopropyl-sulfamic acid [(2,6-diethyl-phenyl)-ethoxymethyl-carbamoyl]-methyl ester 
• 72179-99-8 2-isopropyl-1,1-dioxo-5-phenyl-1,6-dihydro-2H-1λ⁶-[1,2,6]thiadiazin-3-one 
• 136166-38-6 (1-Methylethyl)sulfamic acid 1-phenoxymethyl-1,2-ethanediyl ester 

Relevant articles and documents

2,1,3-Benzothiadiazine derivatives: Synthesis and screening versus PDE4 enzyme

A series of N-1,3 disubstituted 2,1,3-benzothiadiazine derivatives (BTDs) were synthesized and evaluated for their inhibitory activity versus enzymatic isoform PDE4 extracted from U937 cell line. Some of the tested compounds showed a high PDE4 inhibitory activity at 100:μM and the IC50 value of the most interesting terms were evaluated. The structure-activity relationships of these compounds showed that the 3,5-di-tert-butyl-4-hydroxybenzyl moiety at N-1 position is important to obtain activity at micromolar level as previously reported. For the same compounds the antioxidant activity were evaluated highlighting 14 as the most significative one. The introduction of other bulky substituents in N-1 position is detrimental.

3-Azabicyclo[3.1.0]hexane derivatives useful in therapy

Compounds of formula (I), their salts and prodrugs thereof, where the substituents are as defined herein are disclosed as opiate binding agents useful in the treatment of opiate-mediated conditions. Also described are processes for making such substances.

Sulfamates as antiglaucoma agents

Sulfamate esters of the formula where A is aryloxyalkyl, p is the number of unreacted hydroxy groups present on the alkyl moiety and may be zero, z is the number of --OS(O)2 NR1 R2 groups attached to carbons of the alkyl moiety and is always at least one; R1 and R2 are selected from hydrogen, loweralkyl, carboxy, and the like are useful in treating glaucoma.