2612-33-1

Basic information

• Product Name: Clonitrate
• Synonyms: CLONITRATE;(1-Chloro-3-nitrooxypropan-2-yl) nitrate;3-Chloro-1,2-propanediol dinitrate;1-Chloro-2,3-propylene dinitrate;Dinitrochlorhydrin;nitric acid [1-(chloromethyl)-2-nitrooxy-ethyl] ester
• CAS NO: 2612-33-1
• Molecular Formula: C₃H₅ClN₂O₆
• Molecular Weight: 200.53
• Mol File: 2612-33-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: bp760 190-195° (some decompn); bp15 121-123°; bp10 117.5°
• Flash Point: 105.6°C
• Appearance: /
• Density: d9 1.5112; d15 1.5408
• Vapor Pressure: 0.0334mmHg at 25°C
• Refractive Index: 1.6500 (estimate)
• CAS DataBase Reference: Clonitrate(CAS DataBase Reference)
• NIST Chemistry Reference: Clonitrate(2612-33-1)
• EPA Substance Registry System: Clonitrate(2612-33-1)

Safety Data

• Hazardous Substances Data: 2612-33-1(Hazardous Substances Data)

Usage

Uses

Vasodilator (coronary).

Upstream product

• 96-24-2 3-monochloro-1,2-propanediol 
• 106-89-8 epichlorohydrin 
• 4082-08-0 7-hydroxy-2-(4'-hydroxyphenyl)benzopyrilium chloride 
• 7697-37-2 nitric acid 

Relevant articles and documents

Preparation of Di- and polynitrates by ring-opening nitration of epoxides by dinitrogen pentoxide (N2O5)

Eighteen epoxides of various kinds were reacted with N2O5 in chlorinated hydrocarbon solvents (principally CH2Cl2) to give vicinal nitrate ester products by a novel ring-opening nitration reaction. The procedure offers easier temperature control and simpler isolation procedures compared with conventional mixed acid nitrations; it also enables selective nitration reactions to be carried out on polyfunctional substrates. The scope and limitations of the reaction, as well as those of an alternative route utilising N2O4 with in situ oxidation of an intermediate nitrite-nitrate, are discussed.