26130-55-2Relevant academic research and scientific papers
Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements
Large, Jonathan M.,Torr, Jane E.,Raynaud, Florence I.,Clarke, Paul A.,Hayes, Angela,Stefano, Francesca Di,Urban, Frederique,Shuttleworth, Stephen J.,Saghir, Nahid,Sheldrake, Peter,Workman, Paul,McDonald, Edward
scheme or table, p. 836 - 851 (2011/03/19)
Two classes of trisubstituted pyrimidines related to PI-103 1 have been prepared and their inhibitory activities against phosphatidylinositol 3-kinase (PI3K) p110α were determined. From those with direct 6-aryl substitution compound 11a was the most potent inhibitor with an IC50 value of 62 nM, and showed similar activity against other class 1a PI3K isoforms tested, p110β and p110γ. When a linking chain was introduced, as in the second exemplified class, compound 15f inhibited p110α with IC 50 142 nM, and showed greater selectivity towards p110α. Compounds of both classes showed promising inhibition of cellular proliferation in IGROV-1 ovarian cancer cells. Among compounds designed to replace the 3-phenolic motif with structural isosteres, analogues incorporating a 4-indazolyl group possessed enzyme and cellular activities comparable to the parent phenols.
Design, synthesis and evaluation of potential inhibitors of HIV gp120-CD4 interactions
Boussard, Cyrille,Klimkait, Thomas,Mahmood, Naheed,Pritchard, Martin,Gilbert, Ian H.
, p. 2673 - 2676 (2007/10/03)
This paper describes an approach to prevent HIV-cell fusion by disrupting the interaction between HIV protein gp120 and CD4 receptor. The CD4 residues Phe43 and Arg59 make important interactions with gp120. Small molecule analogues were made to mimic the crucial features of these residues. The analogues were assayed using a cellular 'FIGS' assay to measure inhibition of cell fusion and caused some inhibition.
