26131-68-0

Usage

Uses

Used in Medicinal Chemistry:
4-ETHYL-5-PYRIDIN-3-YL-4H-[1,2,4]TRIAZOLE-3-THIOL is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure allows it to form stable complexes with metal ions, making it a potential candidate for the development of metal-based therapeutic agents.
Used in Agriculture:
4-ETHYL-5-PYRIDIN-3-YL-4H-[1,2,4]TRIAZOLE-3-THIOL is used as a pesticide or fungicide in agriculture. Its ability to form stable complexes with metal ions can help protect crops from various diseases and pests.
Used in Materials Science:
4-ETHYL-5-PYRIDIN-3-YL-4H-[1,2,4]TRIAZOLE-3-THIOL is used as a building block for the synthesis of new materials with unique properties. Its reactivity and stability make it a promising candidate for the development of advanced materials with potential applications in various industries.

InChI:InChI=1/C9H10N4S/c1-2-13-8(11-12-9(13)14)7-4-3-5-10-6-7/h3-6H,2H2,1H3,(H,12,14)

Upstream product

• 553-53-7 Nicotinic acid hydrazide 
• 542-85-8 Ethyl isothiocyanate 
• 26036-31-7 4-ethyl-1-(pyridine-3-ylcarbonyl)thiosemicarbazide 
• 93-60-7 methyl 3-pyridinecarboxylate 

Downstream Products

• 880800-32-8 2-((4-ethyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide 
• 525582-84-7 N-(4-ethylphenyl)-2-((4-ethyl-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl)thio)acetamide 
• 142529-66-6 C₁₇H₂₃N₅OS 
• 1412405-92-5 C₂₀H₂₁N₅OS 
• 1412405-97-0 C₂₀H₁₈ClN₅OS 
• 571909-31-4 C₁₉H₂₁N₅OS 
• 333418-84-1 2-((4-ethyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(p-tolyl)acetamide 
• 1412405-83-4 V⁽⁴⁹³⁾U₀₄₄₂ 
• 618426-72-5 018FU 
• 1412405-85-6 018TY 
• 333331-31-0 C₁₉H₁₉N₅O₂S 
• 142529-68-8 C₁₈H₁₉N₅O₂S 
• 142529-64-4 018K₇ 
• 1394326-82-9 2-((4-ethyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-vinylphenyl)acetamide 

Relevant academic research and scientific papers

Narrow SAR in odorant sensing Orco receptor agonists

The systematic exploration of a series of triazole-based agonists of the cation channel insect odorant receptor is reported. The structure-activity relationships of independent sections of the molecules are examined. Very small changes to the compound structure were found to exert a large impact on compound activity. Optimal substitutions were combined using a 'mix-and-match' strategy to produce best-in-class compounds that are capable of potently agonizing odorant receptor activity and may form the basis for the identification of a new mode of insect behavior modification.

Narrow SAR in odorant sensing Orco receptor agonists

The systematic exploration of a series of triazole-based agonists of the cation channel insect odorant receptor is reported. The structure-activity relationships of independent sections of the molecules are examined. Very small changes to the compound structure were found to exert a large impact on compound activity. Optimal substitutions were combined using a 'mix-and-match' strategy to produce best-in-class compounds that are capable of potently agonizing odorant receptor activity and may form the basis for the identification of a new mode of insect behavior modification.

NEW COMPOUNDS

The present invention relates to new compounds of formula I, (I) a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.

The reactions of cyclization of thiosemicarbazide derivatives to 1,2,4-triazole or 1,3,4-thiadiazole system

In the reaction of hydrazide of formic, nicotinic and benzoic acid with isothiocyanates were obtained the respective thiosemicarbazide derivatives [I-XII]. Further cyclization with 2% NaOH solution led to formation of derivatives Δ2-1,2,4-triaz