26148-65-2Relevant academic research and scientific papers
base effect in the auto-tandem palladium-catalyzed synthesis of amino-substituted 1-methyl-1H-α-carbolines
Yadav, Ashok K.,Verbeeck, Stefan,Hostyn, Steven,Franck, Philippe,Sergeyev, Sergey,Maes, Bert U. W.
supporting information, p. 1060 - 1063 (2013/04/10)
An auto-tandem Pd-catalyzed process consisting of an intramolecular direct arylation and an intermolecular Buchwald-Hartwig reaction for C-ring amino-substituted 1-methyl-1H-α-carboline synthesis has been developed. A mechanistic study of the direct arylation reaction revealed a rate effect of the inorganic base on the C-H activation step ( base effect ). The amines, reagents in the tandem protocol, appear to have a similar effect on the direct arylation.
