2615-15-8Relevant articles and documents
Formation of [2]- and [3]Rotaxanes through Bridging under Kinetic and Thermodynamic Control
Fujino, Takaaki,Naitoh, Hirotake,Miyagawa, Shinobu,Kimura, Masaki,Kawasaki, Tsuneomi,Yoshida, Kazuyuki,Inoue, Hajime,Takagawa, Hiroaki,Tokunaga, Yuji
, p. 369 - 372 (2018)
An efficient synthesis of a doubly stranded [3]rotaxane has been developed through bridging of a pseudo[3]rotaxane featuring two axle components. Reversible azine formation was effective as the bridging reaction. Kinetic and thermodynamic conditions provided the [2]- and [3]rotaxanes, respectively.
PROTAC compound for targeted degradation of IDO1, and preparation method and application thereof
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, (2020/06/17)
The invention provides a PROTAC compound represented by formula I and used for targeted degradation of IDO1, and a pharmaceutically acceptable salt, a hydrate or a solvate thereof. In the formula I, Xrepresents -CH2 or -C = O, Y represents -CH2 or -C= O, and n is a natural number from 2 to 9. The PROTAC compound for targeted degradation of the IDO1 has efficient activity of targeted degradation of the IDO1 protein.
Preparation method of organic intermediate hexaethylene glycol
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Paragraph 0014; 0015, (2017/06/02)
The invention provides a preparation method of organic intermediate hexaethylene glycol. The preparation method comprises the following steps of: dissolving tetraglycol in tetrahydrofuran, and adding sodium hydride for reaction; after no hydrogen is released, cooling, dropwise adding tert-butyl bromoacetate for reacting overnight; after reaction is finished, adding water, quenching residual sodium hydride, and extracting with ethyl acetate so as to obtain an intermidate compound A; drying the compound A, mixing with silica gel powder, packing column, performing chromatographic purification, dissolving the purified compound A into tetrahydrofuran, cooling, adding lithium aluminium hydride for reacting overnight; after reaction is finished, adding water, quenching residual lithium aluminium hydride, extracting with small polar impurities with dichloromethane, reserving a water phase, adding ion exchange resin until the pH is neutral, filtering out resin, and performing vacuum concentration on the water phase, thereby obtaining organic intermediate hexaethylene glycol. The preparation method is capable of producing a large amount of hexaethylene glycol, not only is convenient to extract and purify and high in final hexaethylene glycol, but also can be applied to series of high polyethylene glycol products with single synthesis.
