2615-84-1Relevant academic research and scientific papers
Synthesis and evaluation of antibacterial and antitumor activities of new galactopyranosylated amino alcohols
De Souza Fernandes, Fábio,Fernandes, Tayrine Silva,Da Silveira, Lígia Souza,Caneschi, Wiliam,Louren?o, Maria Cristina S.,Diniz, Claudio G.,De Oliveira, Pollyanna Francielli,Martins, Sabrina De Paula Lima,Pereira, Daiane Eleutério,Tavares, Denise Crispim,Le Hyaric, Mireille,De Almeida, Mauro V.,Couri, Mara Rubia C.
, p. 203 - 210 (2015/12/08)
Three series of d-galactose derivatives linked to a lipophilic aminoalcohol moiety were synthesized and their antibacterial activity was evaluated against Mycobacterium tuberculosis and representative species of Gram positive and Gram negative bacteria. Five out of the thirteen tested compounds displayed activity against M. tuberculosis, with a minimal inhibitory concentration (MIC) of 12.5 μg/mL and seven compounds were active against the four bacterial strains tested. The best results were obtained for amino alcohols 10 and 11 against Staphylococcus epidermidis (MIC Combining double low line 2 μg/mL). The antitumor activity was evaluated against three tumor cell lines (MCF-7, HeLa and MO59J) and compared to the normal cell line GM07492A. The results showed that the lowest IC50 values were observed for the amino alcohol 16 against MCF-7 (11.9 μM) and MO59J (10.0 μM).
Synthesis and antileishmanial activity of lipidic amino alcohols
Coimbra, Elaine S.,De Almeida, Mauro V.,Junior, Celso O. R.,Taveira, Aline F.,Da Costa, Cristiane F.,De Almeida, Ana C.,Reis, Elaine F. C.,Da Silva, Adilson D.
scheme or table, p. 233 - 235 (2010/12/20)
In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC50 below 10 μm. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.
