261507-95-3Relevant academic research and scientific papers
Synthesis and Characterization of 5-Substituted 1,3-Diazacyclohexane Derivatives
Axenrod, Theodore,Sun, Jianguang,Das, Kajal K.,Dave, Paritosh R.,Forohar, Farhad,Kaselj, Mira,Trivedi, Nirupam J.,Gilardi, Richard D.,Flippen-Anderson, Judith L.
, p. 1200 - 1206 (2007/10/03)
Three synthetic routes to 5-substituted 1,3-diazacyclohexane derivatives 1 are reported. The first method involves treatment of 1,3-diaminopropan-2-ol 2 with paraformaldehyde to yield 5-hydroxy-1,3-diazacyclohexane 3. A second method is based on the condensation of 2-bromo-2-nitro-1,3-propanediol with tert-butylamine and formaldehyde to yield 1,3-di-tert-butyl-5-bromo-5-nitro-1,3-diazacyclohexane 22. The third method relies on the cycloalkylation of methylenebisacetamide with 3-chloro-2-chloromethyl-2-propene to provide 5-exomethylene-1,3-diacetyl-1,3-diazacyclohexane 28. Functional group manipulations of 3, 22, and 28 provide a number of novel 1,3-diazacyclohexanes functionalized at the 5-position.
