26151-76-8

Basic information

• Product Name: methyl 2-(1-pyridin-2-ylethylidene)hydrazinecarbodithioate
• CAS NO: 26151-76-8
• Molecular Formula: C₉H₁₁N₃S₂
• Molecular Weight: 225.3337
• Mol File: 26151-76-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 355.5°C at 760 mmHg
• Flash Point: 168.8°C
• Density: 1.22g/cm³
• Vapor Pressure: 3.11E-05mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: methyl 2-(1-pyridin-2-ylethylidene)hydrazinecarbodithioate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(1-pyridin-2-ylethylidene)hydrazinecarbodithioate(26151-76-8)
• EPA Substance Registry System: methyl 2-(1-pyridin-2-ylethylidene)hydrazinecarbodithioate(26151-76-8)

Safety Data

• Hazardous Substances Data: 26151-76-8(Hazardous Substances Data)

Upstream product

• 1122-62-9 2-acetylpyridine 
• 5397-03-5 hydrazinecarbodithioic acid methyl ester 

Downstream Products

• 132856-23-6 4-(4-Chloro-phenyl)-piperazine-1-carbothioic acid [1-pyridin-2-yl-eth-(E)-ylidene]-hydrazide 
• 83476-86-2 4-Phenyl-piperidine-1-carbothioic acid N'-(1-pyridin-2-yl-ethyl)-hydrazide 
• 83476-87-3 C₁₅H₂₄N₄S 
• 83476-77-1 C₁₀H₁₆N₄S 
• 83476-76-0 C₁₅H₁₈N₄S 

Relevant articles and documents

Synthesis and antiamoebic activity of new cyclooctadiene ruthenium(II) complexes with 2-acetylpyridine and benzimidazole derivatives

Reaction of [Ru(η4-C8H12) (CH3CN)2 Cl2] with 2-(2-pyridyl) benzimidazole or Schiff bases derived from 2-acetylpyridine and S-methyldithiocarbazate, S-benzyldithiocarbazate and thiosemicarba

Coordination-Mediated Synthesis of 67Ga-Labeled Purification-Free Trivalent Probes for in Vivo Imaging of Saturable Systems

A large excess of unlabeled ligands over gallium-67 (67Ga) provides 67Ga-labeled probes with high radiochemical yields in a short reaction time. However, the unlabeled ligands hinder target accumulation of radiolabeled probes by comp

Heterocyclic dithiocarbazate iron chelators: Fe coordination chemistry and biological activity

The iron coordination and biological chemistry of a series of heterocyclic dithiocarbazate Schiff base ligands is reported with regard to their activity as Fe chelators for the treatment of Fe overload and also cancer. The ligands are analogous to tridentate heterocyclic hydrazone and thiosemicarbazone chelators we have studied previously which bear NNO and NNS donor sets. The dithiocarbazate Schiff base ligands in this work also are NNS chelators and form stable low spin ferric and ferrous complexes and both have been isolated. In addition an unusual hydroxylated ligand derivative has been identified via an Fe-induced oxidation reaction. X-ray crystallographic and spectroscopic characterisation of these complexes has been carried out and also the electrochemical properties have been investigated. All Fe complexes exhibit totally reversible FeIII/II couples in mixed aqueous solvents at potentials higher than found in analogous thiosemicarbazone Fe complexes. The ability of the dithiocarbazate Schiff base ligands to mobilise Fe from cells and also to prevent Fe uptake from transferrin was examined and all ligands were effective in chelating intracellular Fe relative to known controls such as the clinically important Fe chelator desferrioxamine. The Schiff base ligands derived from 2-pyridinecarbaldehyde were non-toxic to SK-N-MC neuroepithelioma (cancer) cells but those derived from the ketones 2-acetylpyridine and di-2-pyridyl ketone exhibited significant antiproliferative activity.