261529-75-3Relevant academic research and scientific papers
Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase
Tillekeratne,Sherette,Grossman,Hupe,Hupe,Hudson
, p. 2763 - 2767 (2001)
Systematic simplification of the molecular structures of epicatechin gallate and epigallocatechin gallate to determine the minimum structural characteristics necessary for HIV-1 reverse transcriptase inhibition in vitro resulted in several compounds that strongly inhibited the native as well as the A17 double mutant (K103N Y181C) enzyme, which is normally insensitive to most known nonnucleoside inhibitors.
MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)
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Page/Page column 52-53; 107, (2020/01/08)
The present invention relates to compounds of formula (I) and salts, stereoisomers, tautomers or N-oxides thereof that are useful as modulators of STING (Stimulator of Interferon Genes). The present invention further relates to the compounds of formula (I) for use as a medicament and to a pharmaceutical composition comprising said compounds.
Process for preparing 3-hydroxymethyl chromen-4-ones
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Page column 1-2, (2010/02/04)
3-(Hydroxymethyl)chromen-4-ones of formula (I) are described and a process for preparing said compounds. The process consists in reacting the compounds of general formula (II) wherein R is hydrogen, halogen, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms optionally substituted by phenyl or halogen, with formaldehyde and a basic catalyst followed by dehydration in an acid medium to form 3-(hydroxymethyl)chromen-4-ones of general formula (I), wherein R is as defined for (II);
A new efficient synthesis of 3-(hydroxymethyl)-4H-chromen-4-ones
Bolos,Loscertales,Nieto,Sacristan,Ortiz
, p. 1203 - 1208 (2007/10/03)
An efficient and versatile synthesis of variously substituted 3-(hydroxymethyl)-4H-chromen-4-ones is reported. The compounds are prepared by hydroxymethylation of the precursor 2-hydroxy-4-chromanones followed by acid dehydration.
