26162-84-5Relevant academic research and scientific papers
Enhancing Ligand-Free Fe-Catalyzed Aminocarbonylation of Alkynes by ZrF4
Huang, Zijun,Dong, Yanan,Li, Yudong,Makha, Mohamed,Li, Yuehui
, p. 5236 - 5240 (2019)
Zirconium fluoride was utilized to promote efficiently iron-catalyzed aminocarbonylation between alkynes and amines without the use of extra ligands. In particular, this new system is applicable to a wide range of amine and alkyne substrates affording α,β-unsaturated amides in good to excellent yields. Preliminary mechanistic studies reveal the activation model involving interactions of ZF4 with both iron catalyst and amine substrates.
