26163-06-4

Basic information

• Product Name: 5-Chloro-N,N-diMethylpyridin-2-aMine
• Synonyms: 5-Chloro-N,N-diMethylpyridin-2-aMine;(5-Chloro-pyridin-2-yl)-diMethyl-aMine
• CAS NO: 26163-06-4
• Molecular Formula: C₇H₉ClN₂
• Molecular Weight: 156.61276
• Mol File: 26163-06-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Chloro-N,N-diMethylpyridin-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-N,N-diMethylpyridin-2-aMine(26163-06-4)
• EPA Substance Registry System: 5-Chloro-N,N-diMethylpyridin-2-aMine(26163-06-4)

Safety Data

• Hazardous Substances Data: 26163-06-4(Hazardous Substances Data)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 244221-57-6 5-chloro-2-iodo-pyridine 

Relevant articles and documents

Amination of Aromatic Halides and Exploration of the Reactivity Sequence of Aromatic Halides

A base-promoted amination of aromatic halides has been developed using a limited amount of dimethylformamide (DMF) or amine as an amino source. Various aryl halides, including F, Cl, Br, and I, have been successfully aminated in good to excellent yields. Although the amination of aromatic halides with amines or DMF is usually considered as an aromatic nucleophilic substitution (SNAr) process, and the reactivity of an aromatic halide is F > Cl > Br > I, the reactivity of aromatic halides in this system was found to be I > Br a‰ F > Cl. This protocol also showed a good regioselectivity for multihalogenated aromatics. This protocol is valuable for industrial application due to the simplicity of operation, the unrestricted availability of amino sources and aromatic halides, transition metal-free conditions, no requirement for solvent, and scalability.