26163-79-1Relevant academic research and scientific papers
(E)-α,β-unsaturated amides from tertiary amines, olefins and CO via Pd/Cu-catalyzed aerobic oxidative N-dealkylation
Shi, Renyi,Zhang, Hua,Lu, Lijun,Gan, Pei,Sha, Yuchen,Zhang, Heng,Liu, Qiang,Beller, Matthias,Lei, Aiwen
, p. 3247 - 3250 (2015)
A novel Pd/Cu-catalyzed chemoselective aerobic oxidative N-dealkylation/carbonylation reaction has been developed. Tertiary amines are utilized as a "reservoir" of "active" secondary amines in this transformation, which inhibits the formation of undesired by-products and the deactivation of the catalysts. This protocol allows for an efficient and straightforward construction of synthetically useful and bioactive (E)-α,β-unsaturated amide derivatives from easily available tertiary amines, olefins and CO. This journal is
