261633-71-0Relevant academic research and scientific papers
Arylalkylamine vanadium (V) salts for the treatment and/or prevention of Diabetes mellitus
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Page/Page column 19; 20, (2010/11/26)
This invention provides compounds of formula (IIA) and pharmaceutical compositions thereof, where M, a, b, and R1-R5 are as defined herein, for treating human type 1 and type 2 diabetes, particularly insulin-resistant diabetes. Pharmaceutical compositions comprising the compounds of formula (IIA) are also disclosed.
Substituted oxygenated heterocycles and thio-analogues: Synthesis and biological evaluation as melatonin ligands
Charton, Isabelle,Mamai, Ahmed,Bennejean, Caroline,Renard, Pierre,Howell, Edward H.,Guardiola-Lemaitre, B.Eatrice,Delagrange, Philippe,Morgan, Peter J.,Viaud, Marie-Claude,Guillaumet, G.Erald
, p. 105 - 114 (2007/10/03)
A new series of substituted oxygenated heterocycles and thio-analogues were synthesized and evaluated as melatonin receptor ligands. The replacement of the indolic moiety of melatonin by heterocyclic skeleton such as 1,4- benzodioxin, 2,3-dihydro-1,4-benzodioxin, chroman, 2,3-dihydro-1,4- benzoxathiin, thiochroman, carrying the amidic chain on the aromatic ring, leads to compounds showing a weak affinity for melatonin receptors, except for the compounds 1cb and 1hb. (C) 2000 Elsevier Science Ltd.
