26172-54-3 Usage
Uses
2-Methyl-4-isothiazolin-3-one Hydrochloride is an isothiazolinone based biocide and preservative used in personal care products. It is also implicated as an allergen. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-containing solution.
Application
Methylisothiazolinone (MIT) has been used: as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell deathto study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites
General Description
2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a derivative of the synthetic isothiazolinone.
Biochem/physiol Actions
2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a skin sensitizer known to cause contact dermatitis and allergy. It is extensively used in the cosmetic industry as a preservative. MIT is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth.
Check Digit Verification of cas no
The CAS Registry Mumber 26172-54-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,1,7 and 2 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 26172-54:
(7*2)+(6*6)+(5*1)+(4*7)+(3*2)+(2*5)+(1*4)=103
103 % 10 = 3
So 26172-54-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H
26172-54-3Relevant articles and documents
Process for preparing 4-isothiazolin-3-one
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, (2008/06/13)
The present invention relates to an improved process for selectively preparing 4-isothiazolin-3-one having the following structural formula(I), consisted of preparing 3,3'-dithiodipropionyldichloride by reacting 3,3'-dithiodipropionic acid with thionylchloride, reacting with amine compound to prepare 3,3'-dithiodipropioneamide, and herein adding sulfrylchloride in organic solvent to cyclize, which is useful as antiseptic or anti-infectives for cooling water, metal processing oils, paints, cosmetics, surfactants, sensitizers, etc. STR1 wherein, R1 is methyl or n-octyl group; R2 is hydrogen or chlorine atom.
