26176-19-2

Usage

Uses

Used in Pharmaceutical Industry:
4,5-DIMETHYL-2-(1H-PYRROL-1-YL)THIOPHENE-3-CARBOXYLIC ACID is used as a potential pharmaceutical agent for drug development due to its unique molecular structure and potential biological activity. Its specific application and efficacy would require additional research and clinical trials to confirm its suitability and safety for medical use.

InChI:InChI=1/C11H11NO2S/c1-7-8(2)15-10(9(7)11(13)14)12-5-3-4-6-12/h3-6H,1-2H3,(H,13,14)

Upstream product

• 26176-14-7 4,5-dimethyl-2-pyrrol-1-yl-thiophene-3-carboxylic acid ethyl ester 
• 4815-24-1 2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester 

Downstream Products

• 153629-53-9 4-Benzyl-piperazine-1-carboxylic acid (4,5-dimethyl-2-pyrrol-1-yl-thiophen-3-yl)-amide 

Relevant academic research and scientific papers

Tricyclic oxime ethers

The present invention relates to compounds of formula (I): STR1 wherein A, x, y, R1, R2 and R3 are as defined in the description. The compounds are useful for treating diseases requiring a selective serotonin reuptake site

Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines

A series of piperazinopyrrolo[1,2-a]thieno[3,2-e]- and -[2,3-e]pyrazine derivatives were prepared and evaluated in order to determine the necessary requirements for high affinity on the 5-HT3 receptors and high selectivity versus other 5-HT receptor subtypes. Various substitutions on the piperazine and the thiophene ring of the pyrrolothienopyrazine moieties were systematically explored as well as replacement of the piperazine by other cyclic amines. The best compounds are in the nanomolar range of affinity for 5-HT3 receptors with high to very high selectivity (up to 10 000 for 14b). These high-affinity compounds have in common a benzyl- or allylpiperazine substituent with no substitutions on the thiophene ring. Five of these compounds (1a, 4b, 13a,b, and 14b) have been evaluated on the Von Bezold- Jarisch reflex and were characterized as partial agonists. One of them, 13a, has shown in vivo at very low dose a potent anxiolytic-like activity in the light/dark test.