261786-35-0Relevant articles and documents
Potent peptide α-ketohydroxamate inhibitors of recombinant human calpain I
Josef, Kurt A.,Kauer, Frederick W.,Bihovsky, Ron
, p. 2615 - 2617 (2007/10/03)
A series of potent dipeptide and tripeptide α-ketohydroxamic esters was prepared as inhibitors of recombinant human calpain I. Compound 3c, a Cbz-Leu-Phe hydroxamate, displayed the greatest potency against calpain I (IC50 = 6 nM), while two compounds, 3l and 3m, both possessing the Cbz-Leu-Leu-Phe sequence, were the most potent (IC50 = 0.2 μM) in a MOLT-4 cell assay.