2618-50-0Relevant articles and documents
Biotransformation of denaverine hydrochloride (Spasmalgan) in the rat
Goeber, B.,Lisowski, Hannelore,Friese, Dagmar,Franke, P.
, p. 493 - 495 (2007/10/02)
After oral application of denaverine hydrochloride to rats (200-250 mg/kg) 12 metabolites have been detected in urine.Besides the unchanged drug, 8 metabolites were identified by MS as 2,2-diphenyl-(2-dimethylaminoethyl)acetate (3), diphenylacetic (5) and benzilic acid (6), methyl- and ethyl acetate (7,11), methylbenzilate (10),N-demethyl-1 (12) and 3,3-diphenylmorpholin-2-one (13). 6 and metabonate 13 represent the main metabolic products.Compounds 7 and 11 indicate the metabolic pathway about an alkoxybenzilic acid (4).Phenols resp. conjugates were not detected.