26186-46-9

Upstream product

• 57009-70-8 2-(3,4,5-trimethoxyphenyl)-1,3-dithiane 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1885-35-4 3,4,5-trimethoxybenzonitrile 

Downstream Products

• 24891-48-3 4-Azido-3',4',5'-trimethoxy-benzophenon 
• 24891-49-4 4-Amino-3',4',5'-trimethoxydiphenylmethane 
• 26186-48-1 4-Amino-3'.4'.5'-trimethoxybenzophenone 

Relevant academic research and scientific papers

Palladium-catalyzed cross-coupling of 2-aryl-1,3-dithianes

Palladium-catalyzed cross-coupling of aryl bromides with 2-aryl-1,3-dithianes is described. This methodology takes advantage of the relatively acidic benzylic proton of the dithiane, allowing it to act as a competent, polarity-reversed transmetalation reagent. This unique approach affords the ability to employ an orthogonal deprotection strategy, and practical routes to both diaryl ketones and diarylmethanes are illustrated. Cross-coupling of a range of aryl dithianes with aryl bromides, including scope and current limitations, is presented.