26197-91-1Relevant academic research and scientific papers
Propargylamine (secondary) as a building block in indole synthesis involving ultrasound assisted Pd/Cu-catalyzed coupling-cyclization method: Unexpected formation of (pyrazole)imine derivatives
Sujeevan Reddy, Gangireddy,Babu Nallapati, Suresh,Sri Saranya,Sridhar,Bhat Giliyaru, Varadaraj,Chandrashekhar Hariharapura, Raghu,Gautham Shenoy,Pal, Manojit
, p. 4587 - 4592 (2018)
Propargylamine (secondary) has been explored as a building block in synthesizing indoles via an ultrasound assisted Pd/Cu-catalyzed coupling-cyclization method. Indoles containing a pyrazole moiety at C-2 attached via the –CH2NH– linker (designed as potential anti-tubercular agents) were synthesized first and then generality/scope of the methodology was expanded by synthesizing other indoles. Unexpected formation of imine side products in first cases helped in synthesizing related (pyrazole)imines via a Cu catalyzed ultrasound assisted aerobic oxidation of precursor amines.
