26199-74-6

Usage

Uses

Used in Pharmaceutical Synthesis:
TRIETHYL ALPHA-PROPARGYLPHOSPHONOACETATE is used as an intermediate for the synthesis of pharmaceutical products, particularly inhibitors and anticancer compounds. Its unique chemical structure allows for the development of novel therapeutic agents with potential applications in various medical fields.
Used in Anticancer Compounds:
In the field of oncology, TRIETHYL ALPHA-PROPARGYLPHOSPHONOACETATE is used as a key component in the synthesis of noncompetitive α-2,3-sialyltransferase inhibitors. These inhibitors play a significant role in the development of targeted cancer therapies, as they can help modulate the activity of enzymes involved in cancer cell growth and progression.
Used in Drug Delivery Systems:
TRIETHYL ALPHA-PROPARGYLPHOSPHONOACETATE can also be utilized in the development of drug delivery systems, where its chemical properties can be harnessed to improve the bioavailability and efficacy of various pharmaceutical agents. By incorporating TRIETHYL ALPHA-PROPARGYLPHOSPHONOACETATE into drug delivery platforms, researchers can potentially enhance the therapeutic outcomes of treatments for a range of diseases, including cancer and other conditions.

InChI:InChI=1/C11H19O5P/c1-5-9-10(11(12)14-6-2)17(13,15-7-3)16-8-4/h1,10H,6-9H2,2-4H3/t10-/m0/s1

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 106-96-7 propargyl bromide 
• 104761-12-8 C₃H₃Na 

Downstream Products

• 54109-54-5 ethyl α-propargyl acrylate 
• 96540-57-7 2-(1-Methyl-2,6-dioxo-cyclohexylmethyl)-pent-4-ynoic acid ethyl ester 
• 136570-82-6 {Ru(C₁₁H₂₀O₅P)Cl(CO)(benzo-2,1,3-selenadiazole)(PPh₃)2} 
• 1205743-67-4 diethyl 2,2'-(1,1'-{1,4-phenylenebismethylenebis[2-diethoxyphosphoryl-3-(1H-1,2,3-triazol-4-yl)]})bispropanoate 
• 96540-55-5 2-(2-Cyano-2-phenyl-ethyl)-pent-4-ynoic acid ethyl ester 
• 96540-60-2 2-(2-Oxo-cyclohexylmethyl)-pent-4-ynoic acid ethyl ester 
• 62873-16-9 5-methyl-3-(methylidene)dihydrofuran-2(5H)-one 
• 176215-09-1 4-(Diethoxy-phosphoryl)-2-methyl-5-oxo-1-(3-phenyl-ureido)-4-prop-2-ynyl-4,5-dihydro-1H-pyrrole-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

INHIBITORS OF METALLO-BETA-LACTAMASE (MBL) COMPRISING A ZINC CHELATING MOIETY

The invention provides compounds according to formula I: A - L - B wherein A represents a lipophilic chelating moiety which is selective for Zn2+ ions; L is a covalent bond or a linker; and B is a vector which is either a moiety capable of interacting with one or more biological structures found in a bacterium (preferably in a bacterial cell wall), for example a penicillin-binding protein such as a metallo-β- lactamase or DD-transferase, or a moiety capable of enhancing transport of the compound across a bacterial cell membrane. Such compounds find use in a method of treating and/or preventing a bacterial infection in a human or non-human mammal. In such a method, the compound of formula I may be administered in combination with (either simultaneously, separately, or sequentially) a β-lactam antibiotic.

Propargyl-substituted phosphonocarboxylates: Efficient synthesis and application to click chemistry

An efficient pathway for the selective preparation of monopropargyl- substituted phosphonocarboxylate (PC) has been developed via the addition of sodium, acetylenide to ethylidenephosphonate. The reaction works perfectly on multi-gram scales. The synthesi

Synthetic Routes to 1-Substituted Butadienylphosphonates

The synthesis of 1-substituted butadienylphosphonates 5 was attempted on three routes.The easily polymerizing butadienes are generally accessible from the stable phosphonates 4 by seleninic acid elimination.

Heterogeneous mediated Alkylation of Ethyl Diethylphosphonoacetate. A "One Pot" Access to α-Alkylated Acrylic Esters

Ethyl diethylphosphonoacetates are α-alkylated in high yield in a heterogeneous reaction with solid potassium carbonate as base.A "one pot" synthesis of α-alkylated acrylic esters is achiewed in a PO-actived olefination reaction aqueous media, when aqueous potassium carbonate and formaldehyde are added directly to the above reaction mixture.

A New Synthesis of 5-Methyl-3-methylene-γ-butyrolactone

An useful synthesis of 5-methyl-3-methylene-γ-butyrolactone (6) involving a Wittig-Horner reaction as a key step is described.

SYNTHESIS OF ETHYL-α- PROPARGYL ACRYLATE - A USEFUL FIVE CARBON SYNTHON

The title compound has been synthesised via an alkylation, Wittig-Horner reaction sequence, Michael addition of several active methylene substrates with compound 1 has been carried out.