26199-74-6 Usage
Description
TRIETHYL ALPHA-PROPARGYLPHOSPHONOACETATE, also known as 2-Phosphono-4-pentynoic Acid Triethyl Ester, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical products. It is characterized by its phosphono and propargyl groups, which contribute to its reactivity and potential applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Synthesis:
TRIETHYL ALPHA-PROPARGYLPHOSPHONOACETATE is used as an intermediate for the synthesis of pharmaceutical products, particularly inhibitors and anticancer compounds. Its unique chemical structure allows for the development of novel therapeutic agents with potential applications in various medical fields.
Used in Anticancer Compounds:
In the field of oncology, TRIETHYL ALPHA-PROPARGYLPHOSPHONOACETATE is used as a key component in the synthesis of noncompetitive α-2,3-sialyltransferase inhibitors. These inhibitors play a significant role in the development of targeted cancer therapies, as they can help modulate the activity of enzymes involved in cancer cell growth and progression.
Used in Drug Delivery Systems:
TRIETHYL ALPHA-PROPARGYLPHOSPHONOACETATE can also be utilized in the development of drug delivery systems, where its chemical properties can be harnessed to improve the bioavailability and efficacy of various pharmaceutical agents. By incorporating this compound into drug delivery platforms, researchers can potentially enhance the therapeutic outcomes of treatments for a range of diseases, including cancer and other conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 26199-74-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,1,9 and 9 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 26199-74:
(7*2)+(6*6)+(5*1)+(4*9)+(3*9)+(2*7)+(1*4)=136
136 % 10 = 6
So 26199-74-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H19O5P/c1-5-9-10(11(12)14-6-2)17(13,15-7-3)16-8-4/h1,10H,6-9H2,2-4H3/t10-/m0/s1
26199-74-6Relevant articles and documents
Synthesis of A-Homo Wieland-Miescher Ketone: A Useful Building Block for Condensed Cycloheptanoid Natural Products
Ravikumar, V. T.,Thangaraj, K.,Swaminathan, S.,Rajagopalan, K.
, p. 985 - 986 (1985)
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Propargyl-substituted phosphonocarboxylates: Efficient synthesis and application to click chemistry
Artyushin, Oleg I.,Osipov, Sergey N.,Roeschenthaler, Gerd-Volker,Odinets, Irina L.
experimental part, p. 3579 - 3588 (2010/03/30)
An efficient pathway for the selective preparation of monopropargyl- substituted phosphonocarboxylate (PC) has been developed via the addition of sodium, acetylenide to ethylidenephosphonate. The reaction works perfectly on multi-gram scales. The synthesi
Heterogeneous mediated Alkylation of Ethyl Diethylphosphonoacetate. A "One Pot" Access to α-Alkylated Acrylic Esters
Kirschleger, Bernard,Queignec, Rene
, p. 926 - 928 (2007/10/02)
Ethyl diethylphosphonoacetates are α-alkylated in high yield in a heterogeneous reaction with solid potassium carbonate as base.A "one pot" synthesis of α-alkylated acrylic esters is achiewed in a PO-actived olefination reaction aqueous media, when aqueous potassium carbonate and formaldehyde are added directly to the above reaction mixture.
