2620-11-3

Basic information

• Product Name: Propanamide, 2-bromo-N-methyl-N-phenyl-
• CAS NO: 2620-11-3
• Molecular Formula: C10H12BrNO
• Molecular Weight: 242.115
• Mol File: 2620-11-3.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Propanamide, 2-bromo-N-methyl-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 2-bromo-N-methyl-N-phenyl-(2620-11-3)
• EPA Substance Registry System: Propanamide, 2-bromo-N-methyl-N-phenyl-(2620-11-3)

Safety Data

• Hazardous Substances Data: 2620-11-3(Hazardous Substances Data)

Upstream product

• 598-72-1 2-Bromopropionic acid 
• 100-61-8 N-methylaniline 
• 7148-74-5 2-Bromopropionyl chloride 
• 563-76-8 α-bromopropionyl bromide 

Downstream Products

• 46988-26-5 N-Methyl-2--propionanilid 

Relevant articles and documents

Enantioconvergent Cu-Catalyzed Radical C-N Coupling of Racemic Secondary Alkyl Halides to Access α-Chiral Primary Amines

α-Chiral alkyl primary amines are virtually universal synthetic precursors for all other α-chiral N-containing compounds ubiquitous in biological, pharmaceutical, and material sciences. The enantioselective amination of common alkyl halides with ammonia is appealing for potential rapid access to α-chiral primary amines, but has hitherto remained rare due to the multifaceted difficulties in using ammonia and the underdeveloped C(sp3)-N coupling. Here we demonstrate sulfoximines as excellent ammonia surrogates for enantioconvergent radical C-N coupling with diverse racemic secondary alkyl halides (>60 examples) by copper catalysis under mild thermal conditions. The reaction efficiently provides highly enantioenrichedN-alkyl sulfoximines (up to 99% yield and >99% ee) featuring secondary benzyl, propargyl, α-carbonyl alkyl, and α-cyano alkyl stereocenters. In addition, we have converted the masked α-chiral primary amines thus obtained to various synthetic building blocks, ligands, and drugs possessing α-chiral N-functionalities, such as carbamate, carboxylamide, secondary and tertiary amine, and oxazoline, with commonly seen α-substitution patterns. These results shine light on the potential of enantioconvergent radical cross-coupling as a general chiral carbon-heteroatom formation strategy.

A copper(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination approach to 2-quinolones

A new cyclisation procedure to prepare 4-carboxy-quinolin-2-ones via a one-pot Cu(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination of linear anilides is described. Extensions to more complex substrates are also reported as are

INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein n, X, Y, Z, D, R1, R2, R3, R4, R12, R15nd R16 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use as modulators of mGluR7.