26203-27-0Relevant academic research and scientific papers
2-Hydroxy-5-[(E)-(4-methoxyphenyl)diazenyl]benzoic acid
Baul, T. S. Basu,Dhar,Tiekink
, (2000)
The compound C14H12N2O4 shows E confirmation about the diazenyl N atoms. The crystal structure features layers of molecules with the primary connection between the layers afforded by carboxylic acid dimer motifs
Synthesis, characterization and radical scavenging activity of aromatic amine conjugates of 5-Aminosalicylic acid
Harveer, Kaur,Jasmeen, Sidana
, p. 475 - 480 (2015/02/02)
5-Aminosalicylic acid is an anti-inflammatory drug used in the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease. Due to its rapid and extensive absorption in the upper gastro-intestinal tract, substantial amount of 5-aminosalicylic acid is already lost before reaching the site of action, i.e. the colon. In order to prevent this loss of drug, carrier linked prodrug approach has been used and azo prodrugs have been synthesized with a purpose of colon targeting. The present research describes the synthesis and characterization of azo prodrugs of 5-aminosalicylic acid with aromatic amines. The synthesized prodrugs were tested for antioxidant activity using DPPH (2,2-diphenyl-1-picrylhydrazy1) free radical scavenging activity. All the synthesized compounds were found to possess mild to moderate radical scavenging activity.
Synthesis and characterization of triorganotin(IV) complexes of 5-[(E)-2-(aryl)-1-diazenyl]-2-hydroxybenzoic acids. Crystal and molecular structures of a series of triphenyltin 5-[(E)-2-(aryl)-1-diazenyl]-2-hydroxybenzoates (aryl = phenyl, 2-methylphenyl, 3-methylphenyl and 4-methoxy...)
Baul, Tushar S. Basu,Dhar, Sushmita,Pyke, Simon M.,Tiekink, Edward R. T.,Rivarola, Eleonora,Butcher, Ray,Smith, Frank E.
, p. 7 - 17 (2007/10/03)
The triphenyltin and tri-n-butyltin complexes of some 5-[(E)-2-(aryl)-1-diazenyl]-2-hydroxybenzoic acids have been synthesized and characterized by 1H-, 13C-, 119Sn-NMR, IR and 119mSn Moessbauer spectroscopic techniques in combination with elemental analysis. The crystal structures of triphenyltin 5-[(E)-2-(aryl-1-diazenyl]-2-hydroxybenzoates (aryl = phenyl, 2-methoxyphenyl, 3-metylphenyl and 4-methoxyphenyl) are reported. Both X-ray and 119Sn Moessbauer data indicate that the triphenyltin complexes adopt a monomeric distorted tetrahedral configuration with the carboxylate ligand coordinating in a monodentate mode. By contrast, 119Sn Moessbauer spectroscopy shows that each tributyltin complex is polymeric and features a trans-trigonal bipyramidal geometry with a planar SnBu3 unit and two apical carboxylate oxygen atoms derived from bidentate bridging carboxylate ligands. This is a solid-state effect, as both 119Sn-NMR and 1(13C-119/117Sn) coupling constant data indicate tetrahedral geometries in solution for the triphenyl and tri-n-butyl complexes.
