26207-67-0

Basic information

• Product Name: 5,7-DIMETHOXY-4'-HYDROXYFLAVANONE
• Synonyms: 5,7-DIMETHOXY-4'-HYDROXYFLAVANONE
• CAS NO: 26207-67-0
• Molecular Formula: C₁₇H₁₆O₅
• Molecular Weight: 300.31
• Mol File: 26207-67-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 524.4°C at 760 mmHg
• Flash Point: 196°C
• Appearance: /
• Density: 1.281g/cm³
• Vapor Pressure: 1.29E-11mmHg at 25°C
• Refractive Index: 1.596
• PKA: 9.63±0.30(Predicted)
• CAS DataBase Reference: 5,7-DIMETHOXY-4'-HYDROXYFLAVANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-DIMETHOXY-4'-HYDROXYFLAVANONE(26207-67-0)
• EPA Substance Registry System: 5,7-DIMETHOXY-4'-HYDROXYFLAVANONE(26207-67-0)

Safety Data

• Hazardous Substances Data: 26207-67-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H16O5/c1-20-12-7-15(21-2)17-13(19)9-14(22-16(17)8-12)10-3-5-11(18)6-4-10/h3-8,14,18H,9H2,1-2H3

Upstream product

• 480-66-0 2,4,6-trihydroxyacetophenone 
• 123-08-0 4-hydroxy-benzaldehyde 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 56798-34-6 4',6'-dimethoxy-2',4-dihydroxychalcone 
• 19158-99-7 (E)-3-(4-(benzyloxy)phenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 37308-75-1 flavokawain C 
• 111316-39-3 4'-benzyloxy-5,7-dimethoxyflavanone 

Downstream Products

• 1386981-14-1 4-(5,7-dimethoxy-4-oxochroman-2-yl)phenyl phenylcarbamate 
• 520-29-6 5,4'-dihydroxy-7-methoxyflavanone 

Relevant articles and documents

Asymmetric Synthesis of Sakuranetin-Relevant Flavanones for the Identification of New Chiral Antifungal Leads

Discovery and efficient synthesis of new promising leads have a central role in agrochemical science. Reported herein is the sakuranetin-directed synergistic exploration of an asymmetric synthesis and an antifungal evaluation of chiral flavanones. A new palladium catalytic system with CarOx-type ligands was successfully identified for the highly enantioselective addition of arylboronic acids to chromones. This enabled the facile and programmable construction of a constellation of chiral flavanones (up to 98% yield and 97% ee), in which (R)-pinostrobin was efficiently constructed without laborious protecting/deprotecting operations. Its good performance in asymmetric induction and functional tolerance expanded the chemical space of pharmaceutically important flavanones. The chiral differentiation of flavanones based on antifungal activity and a concise structure-activity relationship model was disclosed and summarized. This synergistic project culminated with acquisition of the naturally unprecedented flavanones with better antifungal potentials than sakuranetin, in which the R-enantiomer of flavanone 54 (EC50 = 0.8 μM) demonstrated better performance than boscalid against Rhizoctonia solani. The novel scaffold and predicted new target compared with the commercial fungicides in the FRAC reinforce the value of further exploration.

Prenylflavonoid variation in Humulus lupulus: Distribution and taxonomic significance of xanthogalenol and 4'-O-methylxanthohumol

The resins produced by either lupulin or leaf glands of over 120 plants of Humulus lupulus and one plant of H. japonicus (Cannabinaceae) were analyzed for the presence of prenylated flavonoids. The H. lupulus taxa investigated were H. lupulus var. lupulus