26226-49-3

Upstream product

• 854708-26-2 acetic acid-(1-cyclohexyl-2-nitro-propyl ester) 
• 79-24-3 Nitroethane 
• 2043-61-0 cyclohexanecarbaldehyde 
• 87377-90-0 1-cyclohexyl-2-nitropropan-1-ol 

Downstream Products

• 1397266-45-3 (1S,2R)-1-cyclohexyl-2-nitropropyl ethanethioate 
• 52617-05-7 (R)-(-)-1-cyclohexyl-2-propanamine 
• 5913-12-2 (S)-(+)-1-cyclohexyl-2-propanamine 
• 54704-34-6 L-1-methyl-2-cyclohexylethylamine 
• 1351781-84-4 C₁₂H₂₃NO₂ 
• 62527-75-7 (2'-Nitropropyliden)cyclohexan 

Relevant academic research and scientific papers

A diversity-oriented synthesis of polyheterocycles: Via the cyclocondensation of azomethine imine

Pd-Catalyzed sequential reactions to afford skeletally diverse molecules are described. The reaction involved azomethine imine formation and a cyclocondensation reaction as individual steps. The methodology provides excellent regio- and stereocontrol. Skeletal diversity was ensured by changing the electrophilic counterpart of azomethine imine. Due to its broader diversity and complexity, the DOS methodology is likely to benefit drug discovery and development in the future.

Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine

Both enantiomers of several phenylethylamines, structurally related to amphetamine, have been prepared in good yields and excellent enantiomeric purity by enzymatic kinetic resolution using CAL-B and ethyl methoxyacetate as the acyl donor. In the case of the 4-hydroxyderivative of amphetamine (compound 4i), the S enantiomer racemized possibly in a dynamic kinetic resolution (DKR) under the enzymatic conditions used. The Royal Society of Chemistry 2011.

Inter- and Intramolecular Cycloadditions of Nitroalkenes with Olefins. 2-Nitrostyrenes

Aromatic nitroalkenes 9 - 12 underwent Lewis acid catalyzed cycloadditions with various cyclic alkenes to afford high yields of nitronates 25 - 30 with exclusive anti selectivity.Hammett studies helped to further delineate the role of the Lewis acid.Reaction of nitroalkenes 8 and 10 with various cyclic dienes in the presence of a Lewis acid demonstrated the ability of nitroalkenes to behave as dienes in cycloadditions.The major products were the syn diastereomers which arise from an endo-folded transition structure.Finally, intramolecular cycloaddition of 36 - 39 allowed a correlation between the stereochemical course of the reaction and positions of sp2 centers in the tether to be addressed.