262268-63-3Relevant academic research and scientific papers
Regio- and stereoselective synthesis of bromoalkenes by homolytic hydrobromination of alkynes with hydrogen bromide
Kinoshita, Hidenori,Kumaki, Wataru,Miura, Katsukiyo
, (2022/03/07)
Homolytic hydrobromination of terminal and internal alkynes with a commercially available solution of hydrogen bromide in acetic acid has been investigated for regio- and stereoselective synthesis of bromoalkenes. Under an aerobic atmosphere at room temperature, the reaction of ethynylarenes with a small excess of HBr efficiently gave (2-bromoethenyl)arenes with good to high E-selectivity. (Alk-1-ynyl)arenes, or internal alkynes bearing both phenyl and alkyl groups at the sp-carbons also underwent the air-initiated hydrobromination to exhibit high Z-selectivity under kinetic conditions using a half equivalent of HBr.
New method for the synthesis of β-bromostyrenes
Shastin,Nenajdenko,Korotchenko,Balenkova
, p. 1401 - 1405 (2007/10/03)
A new stereoselective method was developed for the synthesis of β-bromostyrenes (E/Z > 5/1) starting from hydrazones of aromatic aldehydes and bromoform in the presence of CuCl.
Phenyl β-methoxyacrylates: A new antimalarial pharmacophore
Alzeer, Jawad,Chollet, Jacques,Heinze-Krauss, Ingrid,Hubschwerlen, Christian,Matile, Hugues,Ridley, Robert G.
, p. 560 - 568 (2007/10/03)
Phenyl β-methoxyacrylates, linked to an aromatic ring via an olefinic bridge, have been identified as novel, potentially inexpensive, antimalarial agents. The compounds are believed to exert their activity by inhibition of mitochondrial electron transport
beta -Alkoxyacrylates against malaria
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, (2008/06/13)
The present invention relates to compounds having the formulae wherein R, R1, R6, R7, Rn8, X, and Z are defined herein, which are useful in the treatment or prophylaxis of malaria. The compounds of the present invention are especially useful in the treatm
