262295-57-8 Usage
General Description
2-(Trifluoromethyl)-4-(piperazin-1-yl)benzonitrile is a chemical compound with the molecular formula C13H10F3N3. It is a benzonitrile derivative that contains a trifluoromethyl group and a piperazin-1-yl group. 2-(TRIFLUOROMETHYL)-4-(PIPERAZIN-1-YL)BENZONITRILE is often used in medicinal chemistry and drug development due to its potential pharmacological properties. It is known for its ability to interact with various biological targets, making it a valuable scaffold for the synthesis of new pharmaceutical compounds. Additionally, the trifluoromethyl group is known to enhance the biological activity and metabolic stability of the compound. Overall, 2-(Trifluoromethyl)-4-(piperazin-1-yl)benzonitrile has the potential to be used in the development of new drugs for various therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 262295-57-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,2,2,9 and 5 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 262295-57:
(8*2)+(7*6)+(6*2)+(5*2)+(4*9)+(3*5)+(2*5)+(1*7)=148
148 % 10 = 8
So 262295-57-8 is a valid CAS Registry Number.
262295-57-8Relevant articles and documents
Synthesis and pharmacological evaluation of novel arylpiperazine derivatives as nonsteroidal androgen receptor antagonists
Kinoyama, Isao,Taniguchi, Nobuaki,Yoden, Toru,Koutoku, Hiroshi,Furutani, Takashi,Kudoh, Masafumi,Okada, Minoru
, p. 1330 - 1333 (2004)
The search for novel antiandrogens by high-throughput screening (HTS) of the Yamanouchi chemical library led to the discovery of the lead compound (5), which possesses an arylmorpholine moiety. Through the optimization of the lead compound (5), we have found a series of novel arylpiperazine derivatives. Among them, 4-[4-cyano-(3-trifluoromethyl)phenyl]-N-(4-fluorophenyl)piperazine-1- carboxamide (22; YM-92088) exhibited a potent AR antagonistic activity with an IC50 value of 0.47 μM in the reporter assay, which is more potent than bicalutamide (4) which has an IC50 value of 0.89 μM.
