262297-44-9

Upstream product

• 262297-32-5 3-[(2S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-2-yl]-isoxazole-5-carboxylic acid ethyl ester 
• 262297-34-7 3-[(2S,4R)-4-Methanesulfonyloxy-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-2-yl]-isoxazole-5-carboxylic acid ethyl ester 
• 262297-35-8 (2S,4R)-2-(5-Hydroxymethyl-isoxazol-3-yl)-4-methanesulfonyloxy-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester 
• 262297-33-6 3-[(2S,4R)-4-Hydroxy-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-2-yl]-isoxazole-5-carboxylic acid ethyl ester 
• 262297-36-9 (2S,4S)-4-Acetylsulfanyl-2-(5-hydroxymethyl-isoxazol-3-yl)-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester 
• 93711-81-0 (4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 
• 262297-37-0 (2S,4S)-2-(5-Hydroxymethyl-isoxazol-3-yl)-4-mercapto-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of new carbapenems containing isoxazole moiety

The synthesis and biological activity of a series of new 1β- methylcarbapenems 1a-g containing 5'-isoxazolopyrrolidin-3'-ylthio derivatives as C-2 side chain are described. Most compounds exhibited potent and well-balanced antibacterial activity as well as high stability to DHP-I comparable to that of meropenem. 1e and 1c showed the best combination of antibacterial activity and stability to DHP-I, respectively.