26235-82-5Relevant academic research and scientific papers
Controlled Reduction of Carboxamides to Alcohols or Amines by Zinc Hydrides
Ong, Derek Yiren,Yen, Zhihao,Yoshii, Asami,Revillo Imbernon, Julia,Takita, Ryo,Chiba, Shunsuke
supporting information, p. 4992 - 4997 (2019/03/13)
New protocols for controlled reduction of carboxamides to either alcohols or amines were established using a combination of sodium hydride (NaH) and zinc halides (ZnX2). Use of a different halide on ZnX2 dictates the selectivity, wherein the NaH-ZnI2 system delivers alcohols and NaH-ZnCl2 gives amines. Extensive mechanistic studies by experimental and theoretical approaches imply that polymeric zinc hydride (ZnH2)∞ is responsible for alcohol formation, whereas dimeric zinc chloride hydride (H?Zn?Cl)2 is the key species for the production of amines.
Mild microwave-assisted synthesis of dipyrromethanes and their analogues
Xiong, Ruisheng,Borbas, K. Eszter
supporting information, p. 484 - 488 (2015/04/14)
The Mannich reaction between pyrroles or indoles and Eschenmoser's salt (dimethylmethylideneammonium iodide) forms N,N-dimethylamino-methylated derivatives in good to excellent yields. The reaction is highly regioselective, and for pyrroles both 2-and 3-s
Rhodium(II) catalyzed intramolecular insertion of carbenoids derived from 2-pyrrolyl and 3-indolyl α-diazo-β-ketoesters and α-diazoketones
Cuevas-Ya?ez, Erick,Muchowski, Joseph M.,Cruz-Almanza, Raymundo
, p. 1505 - 1511 (2007/10/03)
α-Diazo-β-ketoesters and α-diazoketones derived from 2-pyrrolylacetic, 2-pyrrolylpropionic, 3-indolylacetic and 3-indolylpropionic acids afforded carbenoid derived cyclization products on treatment with catalytic rhodium(II) acetate.
1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia
-
, (2008/06/13)
1,3,6-Trihydro-6-Aza-3-Oxapentalen-2-One Derivatives for inhibiting neoplastic conditions.
Photocyclization of Pyrrole Analogues of Stilbene: an Expedient Approach to Antitumor Agent CC-1065
Rawal, Viresh H.,Cava, Michael P.
, p. 1526 - 1527 (2007/10/02)
Described are the preliminary results of a photochemical cyclization based approach to CC-1065; readily available heterocycles are converted into pyrrole analogues of stilbene which are cyclized to give the tricyclic ring structure necessary for CC-1065 a
