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262354-73-4

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262354-73-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 262354-73-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,2,3,5 and 4 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 262354-73:
(8*2)+(7*6)+(6*2)+(5*3)+(4*5)+(3*4)+(2*7)+(1*3)=134
134 % 10 = 4
So 262354-73-4 is a valid CAS Registry Number.

262354-73-4Downstream Products

262354-73-4Relevant articles and documents

Multicomponent assembly of a pyrazine-pillared coordination cage that selectively binds planar guests by intercalation

Kumazawa, Kazuhisa,Biradha, Kumar,Kusukawa, Takahiro,Okano, Takashi,Fujita, Makoto

, p. 3909 - 3913 (2003)

A prismlike cage composed of six end-capped PtII ions, two panel-like ligands, and three pyrazine pillars assembles quantitatively through the template effect of a planar aromatic guest (see space-filling structure). The cage thus obtained is stable even when the template is removed. Other large aromatic molecules are also strongly bound and a β-diketone is shown to exist only in a planar enol form in the cage with the keto-enol tautomerization being almost completely suppressed.

Encapsulation of Pt(IV) prodrugs within a Pt(II) cage for drug delivery

Zheng, Yao-Rong,Suntharalingam, Kogularamanan,Johnstone, Timothy C.,Lippard, Stephen J.

, p. 1189 - 1193 (2015/02/19)

This report presents a novel strategy that facilitates delivery of multiple, specific payloads of Pt(IV) prodrugs using a well-defined supramolecular system. This delivery system comprises a hexanuclear Pt(II) cage that can host four Pt(IV) prodrug guest molecules. Relying on host-guest interactions between adamantyl units tethered to the Pt(IV) molecules and the cage, four prodrugs could be encapsulated within one cage. This host-guest complex, exhibiting a diameter of about 3 nm, has been characterized by detailed NMR spectroscopic measurements. Owing to the high positive charge, this nanostructure exhibits high cellular uptake. Upon entering cells and reacting with biological reductants such as ascorbic acid, the host-guest complex releases cisplatin, which leads to cell cycle arrest and apoptosis. The fully assembled complex displays cytotoxicity comparable to that of cisplatin against a panel of human cancer cell lines, whereas the cage or the Pt(IV) guest alone exhibit lower cytotoxicity. These findings indicate the potential of utilising well-defined supramolecular constructs for the delivery of prodrug molecules.

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