262364-63-6

Upstream product

• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 

Downstream Products

• 3682-75-5 2-(4-methoxyphenyl)-2H-indazole 

Relevant academic research and scientific papers

Pyrazoles for the treatment of obesity and other CNS disorders

This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain pyrazole derivatives, their salts and solvates. These compounds have H3 histamine receptor binding activity. This invention also relates to pharmaceutical compositions containing these compounds and to a method of treating disorders in which histamine H3 receptor modulation is beneficial.

A novel synthesis of 2-aryl-2H-indazoles via a palladium-catalyzed intramolecular amination reaction.

[reaction: see text] A variety of 2-aryl-2H-indazoles were synthesized by the palladium-catalyzed intramolecular amination of the corresponding N-aryl-N(o-bromobenzyl)hydrazines. Of several sets of reaction conditions surveyed, the combination of Pd(OAc)2