262372-11-2Relevant academic research and scientific papers
(D)- and (L)-cyclohexenyl-G, a new class of antiviral agents: Synthesis, conformational analysis, molecular modeling, and biological activity
Wang,Froeyen,Hendrix,Andrei,Snoeck,Lescrinier,De Clercq,Herdewijn
, p. 727 - 730 (2007/10/03)
(D)- and (L)-cyclohexeneyl-G were synthesized enantioselectively starting from (R)-carvone. Both show potent and selective anti-herpesvirus activity (HSV-1, HSV-2, VZV, CMV). Molecular modeling demonstrates that both isomers are bound in the active site o
The cyclohexene ring system as a furanose mimic: Synthesis and antiviral activity of both enantiomers of cyclohexenylguanine
Wang, Jing,Froeyen, Matheus,Hendrix, Chris,Andrei, Graciela,Snoeck, Robert,De Clercq, Erik,Herdewijn, Piet
, p. 736 - 745 (2007/10/03)
Both enantiomers of cyclohexenylguanine were synthesized in a stereospecific way starting from the same starting material: R-(-)-carvone. Both compounds showed potent and selective anti-herpesvirus activity (HSV-1, HSV-2, VZV, CMV). The binding of both cy
