26245-87-4Relevant academic research and scientific papers
Microwave-assisted synthesis of α-aminophosphonates with sterically demanding α-aryl substituents
Hudson, Harry R.,Tajti, ádám,Bálint, Erika,Czugler, Mátyás,Karaghiosoff, Konstantin,Keglevich, Gy?rgy
, p. 1446 - 1455 (2020)
A series of N-benzhydryl protected α-aminophosphonates with α-phenyl, α-(1-naphtyl), α-(9-anthryl) or α-(1-pyrenyl) substituents was synthesized by the Kabachnik–Fields condensation of diphenylmethylamine (benzhydrylamine), the corresponding aryl aldehyde and a dialkyl phosphite under MW irradiation. X-ray studies performed at low temperatures for a few of these α-aminophosphonates confirmed the presence of unusually short intramolecular Cα–Hδ+ ··· δ+H–Cperi contacts.
