262589-84-4

Upstream product

• 68029-68-5 5-chloro-2-hydroxy-3-methylsulfanylbenzoic acid 

Downstream Products

• 262589-75-3 2-[(5-Chloro-2-hydroxy-3-methylsulfinylphenyl)methylthio]-5-(4-fluorophenyl)-4-(4-pyridyl)-1H-imidazole 
• 262589-73-1 4-chloro-2-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-6-methylsulfanyl-phenol 

Relevant academic research and scientific papers

2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS

The invention relates to 2-thio-substituted imidazole derivatives of formula (I), wherein the radicals R1, R2, R3 and m have the meanings as cited in the description. The inventive compounds comprise an immunomodulatory action and/or an action that inhibits the release of cytokines and are thus suited for treating diseases associated with a disorder of the immune system.

Imidazole inhibitors of cytokine release: Probing substituents in the 2 position

Novel 2,4,5-trisubstituted imidazole derivatives were prepared as potential anticytokine agents. Thirty-seven compounds were tested on their ability to inhibit the release of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) from peripheral blood