262614-07-3Relevant articles and documents
Palladium-catalyzed N-monoarylation of amidines and a one-pot synthesis of quinazoline derivatives
McGowan, Meredeth A.,McAvoy, Camille Z.,Buchwald, Stephen L.
supporting information; experimental part, p. 3800 - 3803 (2012/09/10)
A method for the Pd-catalyzed N-arylation of both aryl and alkyl amidines with a wide range of aryl bromides, chlorides, and triflates is described. The reactions proceed in short reaction times and with excellent selectivity for monoarylation. A one-pot synthesis of quinazoline derivatives, via addition of an aldehyde to the crude reaction mixture following Pd-catalyzed N-arylation, is also demonstrated.
