26267-89-0

Basic information

• Product Name: 3,4-Dihydro-2H-pyrano[2,3-b]pyridine
• Synonyms: 3,4-Dihydro-2H-pyrano[2,3-b]pyridine;2H-Pyrano[2,3-b]pyridine, 3,4-dihydro-
• CAS NO: 26267-89-0
• Molecular Formula: C8H9NO
• Molecular Weight: 135.16316
• Mol File: 26267-89-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4-Dihydro-2H-pyrano[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dihydro-2H-pyrano[2,3-b]pyridine(26267-89-0)
• EPA Substance Registry System: 3,4-Dihydro-2H-pyrano[2,3-b]pyridine(26267-89-0)

Safety Data

• Hazardous Substances Data: 26267-89-0(Hazardous Substances Data)

Usage

General Description

3,4-Dihydro-2H-pyrano[2,3-b]pyridine is a chemical compound with a heterocyclic structure that contains both a pyran and a pyridine ring. It is a derivative of pyrano[2,3-b]pyridine and has potential applications in medicinal chemistry due to its ability to modulate biological targets. 3,4-Dihydro-2H-pyrano[2,3-b]pyridine has been studied for its potential as a therapeutic agent for various diseases, including cancer and neurodegenerative disorders. Additionally, 3,4-Dihydro-2H-pyrano[2,3-b]pyridine has demonstrated promising activity as a scaffold for the development of new drug candidates with potential pharmacological activities. Its unique structural features make it an interesting target for further investigation in drug discovery and development.

Upstream product

• 254-67-1 2H-pyrano[2,3-b]pyridine 
• 5390-04-5 pent-1-yn-5-ol 
• 109-04-6 2-bromo-pyridine 
• 128071-75-0 2-bromopyridine-3-carboxaldehyde 
• 1228666-24-7 6-fluoro-3,4-dihydro-2H-pyrano[2,3-b]pyridine 
• 15441-49-3 1-(2-ethoxy-pyridin-3-yl)-propane-1,3-diol 
• 105783-92-4 3-(4-pentynyloxy)-1,2,4-triazine 

Downstream Products

• 115170-38-2 6-bromo-2,3-dihydropyrano<2,3-b>pyridine 

Relevant articles and documents

Palladium-catalyzed hydrodefluorination of fluoroarenes

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Palladium catalyzed hydrodefluorination of fluoro-(hetero)arenes

Palladium catalyzed hydrodefluorination was developed for fine-tuning the properties of fluoro-(hetero)aromatic compounds. The robust reaction can be set up in air, requires only commercially available components, and tolerates a variety of heterocycles and functionalities relevant to drug discovery. Given the prevalence of fluorine incorporation around metabolic hotspots, the corresponding deuterodefluorination reaction may prove useful for converting fluorinated libraries to deuterated analogues to suppress the oxidative metabolism by kinetic isotope effects.

FURTHER INTRAMOLECULAR REACTIONS OF 1,2,4-TRIAZINES. SYNTHESIS OF FUROPYRIDINES AND DIHYDROPYRANOPYRIDINES

3-(3-Butynyloxy)- and 3-(4-pentynyloxy)-1,2,4-triazines undergo facile intramolecular Diels-Alder reactions to yield 2,3-dihydrofuro(2,3-b)pyridines and dihydropyrano(2,3-b)-pyridines respectively.The former are readily dehydrogenated with DDQ to furo(2,3