26269-45-4Relevant academic research and scientific papers
Synthesis and biological activity of analogues of the antimicrotubule agent N,β,β-trimethyl-L-phenylalanyl-N1-[(1S,2E)-carboxy-1- isopropylbut-2-enyl]-N13-dimethyl-L-valinamide (HTI-286)
Zask, Arie,Birnberg, Gary,Cheung, Katherine,Kaplan, Joshua,Niu, Chuan,Norton, Emily,Suayan, Ronald,Yamashita, Ayako,Cole, Derek,Tang, Zhilian,Krishnamurthy, Girija,Williamson, Robert,Khafizova, Gulnaz,Musto, Sylvia,Hernandez, Richard,Annable, Tami,Yang, Xiaoran,Discafani, Carolyn,Beyer, Carl,Greenberger, Lee M.,Loganzo, Frank,Ayral-Kaloustian, Semiramis
, p. 4774 - 4786 (2007/10/03)
Hemiasterlin (1), a tripeptide isolated from marine sponges, induces microtubule depolymerization and mitotic arrest in cells. HTI-286 (2), an analogue from an initial study of the hemiasterlins, is presently in clinical trials. In addition to its potent
