26278-78-4

Basic information

• Product Name: 2-AMINO-6-BENZOTHIAZOLOL HCL
• Synonyms: 2-AMINO-6-BENZOTHIAZOLOL HCL;2-AMINO-6-BENZOTHIAZOLOL HYDROCHLORIDE;2-AMinobenzo[d]thiazol-6-ol hydrochloride;2-AMINOBENZO[D]THIAZOL-6-OL HCL
• CAS NO: 26278-78-4
• Molecular Formula: C₇H₆N₂OS*ClH
• Molecular Weight: 202.66
• Product Categories: pharmacetical
• Mol File: 26278-78-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 263-265 °C
• Boiling Point: 409.2°Cat760mmHg
• Flash Point: 201.3°C
• Appearance: /
• Vapor Pressure: 2.79E-07mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-AMINO-6-BENZOTHIAZOLOL HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-6-BENZOTHIAZOLOL HCL(26278-78-4)
• EPA Substance Registry System: 2-AMINO-6-BENZOTHIAZOLOL HCL(26278-78-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 26278-78-4(Hazardous Substances Data)

Usage

General Description

2-AMINO-6-BENZOTHIAZOLOL HCL is a chemical compound with the molecular formula C7H6N2S·HCl. It is a derivative of benzothiazole and contains an amino group. 2-AMINO-6-BENZOTHIAZOLOL HCL is commonly used in pharmaceutical research and has potential applications in drug development. Its properties and reactivity make it a subject of interest in studies related to organic chemistry and medicinal chemistry. Additionally, the hydrochloride salt form of this compound makes it more water soluble, which can be advantageous for certain applications.

InChI:InChI=1/C7H6N2OS.ClH/c8-7-9-5-2-1-4(10)3-6(5)11-7;/h1-3,10H,(H2,8,9);1H

Upstream product

• 17356-08-0 thiourea 
• 106-51-4 p-benzoquinone 

Downstream Products

• 939-69-5 2-cyano-6-hydroxybenzothiazole 
• 26278-79-5 2-amino-6-hydroxybenzothiazole 
• 64915-59-9 p-nitrobenzyl-6-hydroxybenzothiazole-2-carbamate 
• 58668-52-3 1-(6-hydroxybenzo[d]thiazol-2-yl)-3-phenylurea 

Relevant articles and documents

Synthesis, spectroscopic characterization, and computational studies of 2-cyano-6-hydroxybenzothiazole: A key synthetic intermediate of firefly luciferin

Firefly luciferin is widely applied as a biotechnological tool for visualizing various biological processes in vitro and in vivo. Chemically, 2-cyano-6-hydroxybenzothiazole, as a key synthetic intermediate of firefly luciferin, is obtained from 2-cyano-6-methoxybenzothiazole by changing the methoxy with a hydroxy group. However, this approach is costly and not suited for large-scale synthesis. Here we report cost-effective and efficient syntheses of 2-cyano-6-hydroxybenzothiazole through the catalytic Sandmeyer-type cyanation reaction. Our approach employs diazonium tetrafluoroborate salt of 2-amino-6-hydroxybenzothiazole as a cyanation substrate. The cyanation reaction proceeds efficiently under mild conditions by using Cu(I)/Cu(II)/N,N,N',N'-tetramethylethylenediamine as a catalyst. In addition, computational studies of the 2-cyano-6-hydroxybenzothiazole structure were performed based on the density functional theory method. The theoretical parameters of the optimized geometry were derived from the B3LYP/6-311 ++ G(d, p) method. Time-dependent density functional theory was applied to assign the electronic absorption bands observed experimentally and the1 H NMR chemical shifts were computed using the GIAO method. There was a significant relationship between computational studies and experimental results.

Imidazolothiazole compounds for the treatment of disease

Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.