26286-55-5Relevant articles and documents
Imidazo[1,2-a]pyrazine, Imidazo[1,5-a]quinoxaline and?Pyrazolo[1,5-a]quinoxaline derivatives as IKK1 and IKK2 inhibitors
Patinote, Cindy,Bou Karroum, Nour,Moarbess, Georges,Deleuze-Masquefa, Carine,Hadj-Kaddour, Kamel,Cuq, Pierre,Diab-Assaf, Mona,Kassab, Issam,Bonnet, Pierre-Antoine
, p. 909 - 919 (2017/07/27)
The transcription nuclear factor NF-κB plays a pivotal role in chronic and acute inflammatory diseases. Among the several and diverse strategies for inhibiting NF-κB, one of the most effective approach considered by the pharmaceutical industry seems to be
In vitro and in vivo anti-tumoral activities of imidazo[1,2-a]quinoxaline, imidazo[1,5-a]quinoxaline, and pyrazolo[1,5-a]quinoxaline derivatives
Moarbess, Georges,Deleuze-Masquefa, Carine,Bonnard, Vanessa,Gayraud-Paniagua, Stephanie,Vidal, Jean-Remi,Bressolle, Francoise,Pinguet, Frederic,Bonnet, Pierre-Antoine
, p. 6601 - 6610 (2008/12/22)
Imidazoquinoxaline and pyrazoloquinoxaline derivatives, analogues of imiquimod, were synthesized, and their in vitro cytotoxic and pharmacodynamic activities were evaluated. In vitro cytotoxicity studies were assessed against melanoma (A375, M4Be, RPMI-75
Efficient ligand-mediated ullmann coupling of anilnies and azoles
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, (2008/06/13)
The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa inhibitors.