262863-77-4Relevant academic research and scientific papers
Access to 1: H -indazoles, 1 H -benzoindazoles and 1 H -azaindazoles from (het)aryl azides: A one-pot Staudinger-aza-Wittig reaction leading to N-N bond formation?
Alaime,Daniel,Hiebel,Pasquinet,Suzenet,Guillaumet
, p. 8411 - 8414 (2018)
The synthesis of various substituted 1H-indazoles is reported through N-N bond formation from an iminophosphorane derivative. Supported by control experiments, an original Staudinger-aza-Wittig tandem mechanism is proposed for this transformation.
Dehydrophenylalanine derivatives as VLA-4 integrin antagonists
Porter, John R.,Archibald, Sarah C.,Brown, Julien A.,Childs, Kirstie,Critchley, David,Head, John C.,Parton, Ted A. H.,Robinson, Martyn K.,Shock, Anthony,Taylor, Richard J.,Warrellow, Graham J.
, p. 805 - 808 (2007/10/03)
We describe a series of dehydrophenylalanine derivatives where the Z isomers are potent VLA-4 antagonists but are subject to rapid biliary clearance and the E isomers have poor activity but have a slower rate of clearance. These configurationally constrained molecules have led to the design of a novel class of benzodiazepine VLA-4 antagonists.
