26295-49-8

Upstream product

• 26295-42-1 1’-(4-phenyl-[1,2,3]-triazol-1-yl)-2’,3’,4’,6’-tetra-O-acetyl-β-D-glucopyranose 
• 536-74-3 phenylacetylene 
• 13992-25-1 1-azido-1-deoxy-β-D-glucopyranoside tetraacetate 
• 20379-59-3 D-glucopyranosyl azide 
• 1068437-14-8 4-phenyl-1-[2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-D-glucopyranosyl]-1H-[1,2,3]triazole 
• 4163-60-4 β-D-galactose peracetate 
• 26295-42-1 (2R,3S,4S,5R,6R)-2-(acetoxymethyl)-6-(4-phenyl-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 13992-26-2 (2R,3S,4S,5R,6R)-2-(acetoxymethyl)-6-azidotetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 35899-89-9 1-amido-1-deoxygalactopyranose 
• 3068-32-4 1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside 

Relevant academic research and scientific papers

Oxaliplatin derived monofunctional triazole-containing platinum(II) complex counteracts oxaliplatin-induced drug resistance in colorectal cancer

Oxaliplatin-based chemotherapy is the current standard of care in adjuvant therapy for advanced colorectal cancer (CRC). But acquired resistance to oxaliplatin eventually occurs and becoming a major cause of treatment failure. Thus, there is an unmet need

Efficient atropodiastereoselective access to 5,5′-bis-1,2,3- triazoles: Studies on 1-glucosylated 5-halogeno 1,2,3-triazoles and their 5-substituted derivatives as glycogen phosphorylase inhibitors

Whereas copper-catalyzed azide-alkyne cycloaddition (CuAAC) between acetylated β-D-glucosyl azide and alkyl or phenyl acetylenes led to the corresponding 4-substituted 1-glucosyl-1,2,3-triazoles in good yields, use of similar conditions but with 2 equiv C

Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties

A series of novel glycopyranosyl azides were synthesised wherein the carbohydrate moiety was peracylated with four acetyl, propionyl, butanoyl, pentanoyl (valeryl) or 3-methylbutanoyl (isovaleryl) ester linked groups. A panel of glycoconjugates was synthe

A versatile solvent-free azide-alkyne click reaction catalyzed by in situ generated copper nanoparticles

A general, high-yielding and efficient methodology for the copper catalyzed azide-alkyne cycloaddition (CuAAC) reaction catalyzed by in situ generated copper nanoparticles (CuNPs) or their clusters is reported. This simple reaction is facile in water, org

Copper catalyst activation driven by photoinduced electron transfer: A prototype photolatent click catalyst

PET cat. While the copper(II) tren ketoprofenate precatalyst 1 (see picture) is inactive at room temperature in methanol, it is quantitatively and rapidly reduced to its cuprous state upon light irradiation to provide a highly reactive click catalyst. By simply introducing air into the reaction medium the catalysis can be switched off and then switched on again by bubbling argon followed by irradiation. Copyright

Synthesis of α- and β-d-glucopyranosyl triazoles by CuAAC 'click chemistry': reactant tolerance, reaction rate, product structure and glucosidase inhibitory properties

CuI-catalysed azide alkyne 1,3-dipolar cycloaddition (CuAAC) 'click chemistry' was used to assemble a library of 21 α-d- and β-d-glucopyranosyl triazoles, which were assessed as potential glycosidase inhibitors. In the course of this work, diff

Synthesis of 1-(d-glucopyranosyl)-1,2,3-triazoles and their evaluation as glycogen phosphorylase inhibitors

1-(d-Glucopyranosyl)-1,2,3-triazoles were prepared from per-O-acetylated α- and β-d-glucopyranosyl azides as well as per-O-benzoylated (β-d-gluco-hept-2-ulopyranosylazide)onamide and onic acid methylester by using azide-alkyne cycloaddition catalysed by i

Effects of a flexible alkyl chain on a ligand for CuAAC reaction

Imidazole derivatives substituted by a normal alkyl group are shown to be efficient as a ligand for the copper(Δ)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. An alkyl chain on the imidazole ligands shows an efficient steric effect and benefits the reaction. Such functionalities of an alkyl chain allow a rapid CuAAC reaction of even a bulky alkyne, which has been difficult to perform under conventional conditions.

Synthesis of some novel glucosyl triazoles from 2,3,4,6-tetra-O-pivaloyl-D- glucopyranosyl azide

In the present study, we have synthesized a series of novel glucosyl triazoles for the first time. The glucosyl triazoles 4a-e were synthesized by reaction of some azidoglycosides with various terminal alkynes via a copper-catalyzed [3+2] cycloaddition ("

Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case

Per-O-acetylated β-d-glucopyranosyl azide was transformed into an intermediate iminophosphorane by PMe3 which was then acylated to N-acyl-β-d-glucopyranosylamines. The same azide and substituted acetylenes gave 1-(β-d-glucopyranosyl)-4-substitu