2631-02-9

Usage

Type

Synthetic opioid

Use

Pain medication and anesthesia

Mechanism of action

Binds to the body's opioid receptors in the brain and spinal cord to produce pain relief and feelings of euphoria

Potency

High, with effects similar to morphine but many times stronger

Risks

High risk of addiction, overdose, and respiratory depression, especially when used improperly or in combination with other drugs

Legal status

Controlled substance with closely regulated medical use.

Upstream product

• 3516-95-8 2'-hydroxy-3-phenylpropiophenone 
• 110-89-4 piperidine 
• 2525-99-7 2-(4-Brom-butoxy)-β-phenyl-propiophenon 

Relevant academic research and scientific papers

Studies on propafenone-type modulators of multidrug resistance VI. Synthesis and pharmacological activity of compounds with varied spacer length between the central aromatic ring and the nitrogen atom

A series of propafenone-type modulators of multidrug resistance (MDR) with varied spacer length between the central aromatic ring and the positively chargeable nitrogen atom was synthesized and tested for their ability to block P-glycoprotein-mediated transport of daunomycin out of tumor cells. Synthesis was achieved by O-alkylation of o-hydroxy-3- phenylpropiophenone with dibromoalkanes and subsequent nucleophilic substitution of the bromine with piperidine. All compounds showed high MDR- modulating activity with EC50 values from 1.450.15 μM. Generally, activity increased with increasing number of methylene groups, whereby it reaches a plateau for compounds with more than five methylene groups between the ether oxygen and the nitrogen atom.