263262-04-0

Basic information

• Product Name: methyl N-methoxycarbonyl-N-methylphenylalaninate
• Synonyms: methyl N-methoxycarbonyl-N-methylphenylalaninate
• CAS NO: 263262-04-0
• Molecular Weight: 251.282
• Mol File: 263262-04-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl N-methoxycarbonyl-N-methylphenylalaninate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl N-methoxycarbonyl-N-methylphenylalaninate(263262-04-0)
• EPA Substance Registry System: methyl N-methoxycarbonyl-N-methylphenylalaninate(263262-04-0)

Safety Data

• Hazardous Substances Data: 263262-04-0(Hazardous Substances Data)

Upstream product

• 41844-71-7 methyl (S)-2-methoxycarbonylamino-3-phenyl-propionate 
• 74-88-4 methyl iodide 

Downstream Products

• 263261-71-8 N-(methoxycarbonyl)-N-methyl-L-phenylalanine 

Relevant articles and documents

The Dakin-West reaction of N-alkoxycarbonyl-N-alkyl-α-amino acids employing trifluoroacetic anhydride

The Dakin-West reaction of N-alkoxycarbonyl-N-alkyl-α-amino acids (1a - j) with trifluoroacetic anhydride in the presence of pyridine gave α-amido trifluoromethyl ketones (2a - j), in which probable intermediates were mesoionic 1,3-oxazolium-5-olates (munchnones). The diastereoselective reduction of 2a - f with NaBH4 gave the threo-aminoalcohols (5a - f), which may be explained by the Felkin-Anh model. This was confirmed by converting 5a - f into trans-5-trifluoromethyl-2-oxazolidinones (6a - f) in good yields.