263276-08-0Relevant articles and documents
Discovery and evaluation of N-(triazin-1,3,5-yl) phenylalanine derivatives as VLA-4 integrin antagonists.
Porter, John R,Archibald, Sarah C,Brown, Julien A,Childs, Kirstie,Critchley, David,Head, John C,Hutchinson, Brian,Parton, Ted A H,Robinson, Martyn K,Shock, Anthony,Warrellow, Graham J,Zomaya, Alex
, p. 1591 - 1594 (2002)
SAR studies aimed at improving the rate of clearance of a series of VLA-4 integrin antagonists by the introduction of a 1,3,5-triazine as an amide isostere are described.
Phenylalanine derivatives
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Page column 20, (2010/01/30)
Phenylalanine derivatives of formula (1) are described: in which:Ar1 is an aromatic or heteroaromatic group;L1 is a linker atom or group;R is a carboxylic acid or a derivative thereof;Ar2 is an optionally substituted aromatic or heteroaromatic group;and the salts, solvates, hydrates and N-oxides thereof.The compounds are able to inhibit the binding of à4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.