263339-24-8

Usage

Uses

Used in Cardiology:
4-(4-aminobenzyl)-1LAMBDA6,4-thiazinane-1,1-dione is used as an antiarrhythmic medication for the treatment and prevention of serious, life-threatening ventricular arrhythmias. It works by stabilizing the heart's electrical activity and reducing abnormal rhythms, making it an important medication for managing specific heart rhythm disorders.
Used in Pharmaceutical Industry:
4-(4-aminobenzyl)-1LAMBDA6,4-thiazinane-1,1-dione is used as a key ingredient in the formulation of antiarrhythmic drugs. Its ability to stabilize the heart's electrical activity and reduce abnormal rhythms makes it a valuable component in the development of medications for the treatment and prevention of life-threatening ventricular arrhythmias.

InChI:InChI=1/C11H16N2O2S/c12-11-3-1-10(2-4-11)9-13-5-7-16(14,15)8-6-13/h1-4H,5-9,12H2

Upstream product

• 77-77-0 Divinyl sulfone 
• 4403-71-8 (4-aminomethyl)aniline 

Downstream Products

• 929891-01-0 4'-[4-(1,1-dioxo-1λ6-thiomorpholin-4-ylmethyl)-phenylcarbamoyl]-6-methyl-biphenyl-3-carboxylic acid methyl ester 
• 929891-27-0 5'-cyano-2'-methyl-biphenyl-4-carboxylic acid [4-(1,1-dioxo-1λ6-thiomorpholin-4-ylmethyl)-phenyl]-amide 
• 1056635-99-4 N-(cyanomethyl)-4-[2-((4-[(1,1-dioxo-1λ6,4-thiomorpholin-4-yl)methyl]phenyl)amino)pyrimidin-4-yl]benzamide 
• 1132825-60-5 5-bromo-thiophene-2-carboxylicacid[4-(1,1-dioxo-1lambda-*6*-thiomorpholin-4-ylmethyl)-phenyl]-amide 
• 1132825-13-8 4-[2-methyl-5-(4-morpholin-4-yl-phenylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid [4-(1,1-dioxo-1lambda-*6*-thiomorpholin-4-ylmethyl)-phenyl]-amide 
• 1197010-60-8 C₂₂H₂₅N₅O₄S₂ 
• 1240501-34-1 N-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 
• 929891-59-8 3-bromo-N-[4-(1,1-dioxo-1λ6-thiomorpholin-4-ylmethyl)-phenyl]-4-methoxy-benzamide 
• 1132824-77-1 5-[2-methyl-5-(4-morpholin-4-yl-phenylcarbamoyl)-phenyl]-furan-2-carboxylic acid [4-(1.1-dioxo-1lambda-*6*-thiomorpholin-4-ylmethyl)-phenyl]-amide 

Relevant academic research and scientific papers

NON-ATP/CATALYTIC SITE P38 MITOGEN ACTIVATED PROTEIN KINASE INHIBITORS

Compounds that inhibit p38a MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.

NON-ATP/CATALYTIC SITE p38 MITOGEN ACTIVATED PROTEIN KINASE INHIBITORS

Compounds that inhibit p38α MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.

Substituted indolines which inhibit receptor tyrosine kinases

Indolinones of the formula having an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well as on the proliferation of endothelial cells and various tumor cells. Exemplary are: (a) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-ethoxycarbonyl-2-indolinone, (b) 3-Z-[(1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-carbamoyl-2-indolinone, and (c) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-metboxycarbonyl-2-indolinone.

Substituted indolinones with kinase inhibitory activity

Substituted indolinones of general formula having effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells. Exemplary compounds are: 3-Z-[1-(4-(N-Benzyl-N-methyl-aminomethyl)-phenylamino)-1-methyl-methylene]-5-a