263339-37-3Relevant academic research and scientific papers
Substituted indolinones, their manufacture and their use as medicaments
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Page/Page column 21, (2010/02/08)
The present invention relates to substituted indolinones of general formula wherein R1to R6and X are defined as in claim 1, the isomers and the salts thereof, in particular the physiologically acceptable salts thereof which have valuable pharmacological properties, especially an inhibitory effect on various receptor-tyrosine kinases, and cycline/CDK complexes as well as on the proliferation of endothelial cells and various tumor cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
