263390-85-8Relevant articles and documents
Identification of 2,3-disubstituted pyridines as potent, orally active PDE4 inhibitors
Kato, Yoshihiro,Kawasaki, Motoji,Nigo, Tomohiro,Nakamura, Shunya,Fusano, Akira,Teranishi, Yasuhiro,Ito, Mari N.,Sumiyoshi, Takaaki
, p. 5851 - 5854 (2013/09/12)
A series of 2,3-disubstituted pyridines were synthesized and evaluated for their PDE4 inhibitory activity. We successfully modified undesirable cyano group of initial lead compound 2 to 4-pyridyl group with improvement of in vitro efficacy and optimized t