263397-88-2Relevant academic research and scientific papers
2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors
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, (2008/06/13)
Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R1represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid agonist activity.
2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors
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, (2008/06/13)
Compounds of Formula 1, Formula 2 or Formula 3 where X is O, S, or (CR1R1)n where n is 0, 1 or 2; Y is a bivalent radical having Formula 4 or Formula 5 where o is an integer from 1 to 4 or Y is a bivalent aryl or 5 or 6 membered heteroaryl radical having 1 to 3 heteroatoms selected from N, S and O, said aryl or heteroaryl groups being unsubstituted, or substituted with 1 to 3 C1-6 alkyl or with 1 to 3 C1-6 fluoroalkyl groups; and the remaining symbols have the meaning described in the specification, have RXR selective retinoid agonist-like activity.
