26340-00-1

Basic information

• Product Name: .trans.-1,3-dibenzyl-dihydro-1H-furo[3,4-d]imidazole-2,4,6(3H)-trione
• Synonyms: .trans.-1,3-dibenzyl-dihydro-1H-furo[3,4-d]imidazole-2,4,6(3H)-trione
• CAS NO: 26340-00-1
• Molecular Formula: C19H16N2O4
• Molecular Weight: 336.34134
• EINECS: 247-621-5
• Mol File: 26340-00-1.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 597.3°Cat760mmHg
• Flash Point: 315°C
• Appearance: /
• Density: 1.388g/cm³
• Vapor Pressure: 3.13E-14mmHg at 25°C
• Refractive Index: 1.652
• PKA: -1.25±0.20(Predicted)
• CAS DataBase Reference: .trans.-1,3-dibenzyl-dihydro-1H-furo[3,4-d]imidazole-2,4,6(3H)-trione(CAS DataBase Reference)
• NIST Chemistry Reference: .trans.-1,3-dibenzyl-dihydro-1H-furo[3,4-d]imidazole-2,4,6(3H)-trione(26340-00-1)
• EPA Substance Registry System: .trans.-1,3-dibenzyl-dihydro-1H-furo[3,4-d]imidazole-2,4,6(3H)-trione(26340-00-1)

Safety Data

• Hazardous Substances Data: 26340-00-1(Hazardous Substances Data)

Usage

Description

.trans.-1,3-dibenzyl-dihydro-1H-furo[3,4-d]imidazole-2,4,6(3H)-trione is a complex chemical compound characterized by a dihydro-1H-furo[3,4-d]imidazole-2,4,6(3H)-trione backbone. This trione compound features a furan ring fused to an imidazole ring, with three carbonyl groups attached to the imidazole ring. The incorporation of benzyl groups in the structure suggests the substitution of hydrogen atoms with benzyl groups, which may contribute to its unique properties and potential applications.

Uses

Used in Pharmaceutical Research:
.trans.-1,3-dibenzyl-dihydro-1H-furo[3,4-d]imidazole-2,4,6(3H)-trione is used as a compound of interest in pharmaceutical research due to its unique chemical structure and potential biological activity. Its specific application reason is the possibility of it being developed into a pharmaceutical agent, given its distinctive backbone and functional groups.
Used in Drug Development:
In the field of drug development, .trans.-1,3-dibenzyl-dihydro-1H-furo[3,4-d]imidazole-2,4,6(3H)-trione is used as a starting point for the design and synthesis of new drugs. The application reason is its potential to be modified and optimized to target specific biological pathways or receptors, which could lead to the creation of novel therapeutics.

InChI:InChI=1/C19H16N2O4/c22-17-15-16(18(23)25-17)21(12-14-9-5-2-6-10-14)19(24)20(15)11-13-7-3-1-4-8-13/h1-10,15-16H,11-12H2/t15-,16-/m0/s1

Upstream product

• 59564-78-2 2-oxo-1,3-dibenzyl-cis-4,5-imidazolidinedicarboxylic acid 
• 21035-81-4 (3aRS,6SR,6aSR)-1,3-dibenzyl-6-hydroxy-3,3a,6,6a-tetrahydro-1H-furo<3,4-d>imidazole-2,4-dione 
• 28092-55-9 Acetic acid (3aR,4R,6aS)-1,3-dibenzyl-2,6-dioxo-hexahydro-furo[3,4-d]imidazol-4-yl ester 
• 51591-75-4 cis-1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid 
• 129388-92-7 (3aR,6S,6aS)-1,3-dibenzyl-6-hydroxy-3,3a,6,6a-tetrahydro-1H-furo<3,4-d>imidazole-2,4-dione 
• 108-24-7 acetic anhydride 

Downstream Products

• 28092-62-8 (3aS,6aR)-1,3-dibenzyltetrahydro-1H-furo[3,4-d]imidazole-2,4-dione 
• 87585-00-0 (4S,5R)-1,3-dibenzyl-5-hydroxymethyl-2-oxoimidazolidine-4-carboxylic acid lactone 

Relevant articles and documents

METHOD FOR PRODUCING AMIDE CARBOXYLIC ACID COMPOUND, AND METHOD FOR PRODUCING AMIDE ALCOHOL COMPOUND, AND METHOD FOR PRODUCING LACTONE COMPOUND

PROBLEM TO BE SOLVED: To provide a production method for efficiently obtaining a high-purity amide carboxylic acid compound, which is useful as a synthetic intermediate of biotin. SOLUTION: In a method for producing an amide carboxylic acid compound, an anhydride of a specific ureido compound is brought into contact with an optically active amine such as N-Me-R-α-methyl benzyl amine to obtain a mixture comprising an amide carboxylic acid compound, and then, the amide carboxylic acid compound is isolated from the obtained mixture. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Method for stereoselectively synthesizing chiral lactone, chiral compound and application of chiral compound

The invention relates to the field of organic synthesis, and discloses a method for stereoselectively synthesizing chiral lactone, a chiral compound and application of the chiral compound in synthesis of biotin. The method comprises the following steps: (1) carrying out first reaction on cyclic anhydride, cyclic chiral alcohol and organic alkali tertiary amine to obtain dicarboxylic acid mono-ester quaternary ammonium salt; (2) carrying out second reaction on the dicarboxylic acid mono-ester quaternary ammonium salt and a reducing agent after intermediate treatment or no intermediate treatment to obtain alcohol acid; and (3) under an acidic condition, carrying out a third reaction on the alcohol acid to obtain the chiral lactone shown in the formula (I). According to the method disclosed by the invention, the target product can be obtained with high selectivity and high yield.

Chiral squaramide-mediated methanolytic desymmetrization of prochiral cyclic anhydride: A convenient approach for synthesizing roche lactone

The main objective of this report was to develop an improved process for the asymmetric synthesis of (3aS, 6aR)-lactone 1, which is the key chiral intermediate of (+)-biotin. This practical and efficient process includes a novel chiral squaramide alkamine derivatives 5 mediated methanolytic desymmetrization of prochiral cyclic anhydride 3 to produce the enantiomerically enriched precursor of Roche lactone.